Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Translational Control Of Stress Induced Breast Cancer Plasticity, Michael Jewer
Translational Control Of Stress Induced Breast Cancer Plasticity, Michael Jewer
Electronic Thesis and Dissertation Repository
Cancer cell plasticity, whereby stem-cell-like properties are acquired in response to stress, represents a major challenge in cancer treatment. Using cell line and patient-derived xenograft (PDX) models, we demonstrate that translational reprogramming occurs in response to stresses such as hypoxia and chemotherapy which elicits stem cell properties in breast cancer. Other stresses like chemotherapy demonstrate the translational inhibition that has been well characterized as an integral hypoxic cellular response. The inhibition of translation is primarily regulated at initiation by mTOR/4E-BP1 and PERK/eIF2α signalling. We identify previously undescribed 5’ untranslated regions (5’UTRs) of plasticity-associated genes like NANOG, SNAIL and NODAL. …
Investigating The Role Of Tp53inp1 And Tp53inp2 In Neuronal Autophagy And Mitophagy, Vidhyasree Shyam
Investigating The Role Of Tp53inp1 And Tp53inp2 In Neuronal Autophagy And Mitophagy, Vidhyasree Shyam
Electronic Thesis and Dissertation Repository
Autophagy is highly conserved cellular process that functions in ensuring the turnover of proteins and organelles in a number of different cell types. Mitophagy is a selective form of autophagy which serves to target and rid the cell of damaged or superfluous mitochondria. The process is central to preventing the accumulation of defective mitochondria and is particularly important in neurons, which rely exclusively on mitochondria to sustain their immense metabolic needs. Dysregulation of autophagy is believed to contribute to the neurodegeneration seen in such disorders as Parkinson’s disease and cerebral ischemia. However, further understanding of the role of neuronal autophagy …