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Ampk Signalling As A Regulator Of Autophagy In A Model Of Ovarian Tumour Dormancy, Jeremi Laski
Ampk Signalling As A Regulator Of Autophagy In A Model Of Ovarian Tumour Dormancy, Jeremi Laski
Electronic Thesis and Dissertation Repository
One of the hallmarks of epithelial ovarian cancer (EOC) metastasis lies in the process of spheroid formation, whereby tumour cells aggregate into 3D structures. Previous literature suggests that as EOC cells form spheroids they undergo bioenergetic stress, activate AMP-activated protein kinase (AMPK) signaling, and thereby force cells to enter a metabolically quiescent state. We have previously shown that EOC spheroids up- regulate autophagy, a process that provides energy during starvation conditions. Herein, I examined the role of AMPK-mediated signaling regulation of autophagy in a model of ovarian tumour dormancy. Attenuation of AMPK signaling in EOC spheroids resulted in reduction of …
Investigating The Role Of Tp53inp1 And Tp53inp2 In Neuronal Autophagy And Mitophagy, Vidhyasree Shyam
Investigating The Role Of Tp53inp1 And Tp53inp2 In Neuronal Autophagy And Mitophagy, Vidhyasree Shyam
Electronic Thesis and Dissertation Repository
Autophagy is highly conserved cellular process that functions in ensuring the turnover of proteins and organelles in a number of different cell types. Mitophagy is a selective form of autophagy which serves to target and rid the cell of damaged or superfluous mitochondria. The process is central to preventing the accumulation of defective mitochondria and is particularly important in neurons, which rely exclusively on mitochondria to sustain their immense metabolic needs. Dysregulation of autophagy is believed to contribute to the neurodegeneration seen in such disorders as Parkinson’s disease and cerebral ischemia. However, further understanding of the role of neuronal autophagy …