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The Effect Of Seizures (Afterdischarges) On Hippocampal Long-Term Potentiation, Vishaka Rajan
The Effect Of Seizures (Afterdischarges) On Hippocampal Long-Term Potentiation, Vishaka Rajan
Electronic Thesis and Dissertation Repository
This study investigated whether an electrographic seizure, or an afterdischarge (AD), inhibits long-term potentiation (LTP) in the hippocampus. Neuromodulation by acetylcholine (ACh) and genetic modification by loss of the ATRX gene on LTP was also examined through the use of VAchT knockout mice and ATRX knockout mice, respectively. Evoked potentials were recorded in the hippocampal CA1 region in freely behaving mice and urethane-anesthetized mice. Basal dendritic LTP was suppressed when elicited 1 h after an AD in all behaving mice, regardless of mouse genotype; LTP was unaffected when induced 1 day or 1 week following an AD. At 1 h …
Object Processing In The Medial Temporal Lobe: Influence Of Object Domain, Anna Blumenthal
Object Processing In The Medial Temporal Lobe: Influence Of Object Domain, Anna Blumenthal
Electronic Thesis and Dissertation Repository
We live in a rich visual world, surrounded by many different kinds of objects. While we may not often reflect on it, our ability to recognize what an object is, detect whether an object is familiar or novel, and bring to mind our general knowledge about an object, are all essential components of adaptive behavior. In this dissertation, I investigate the neural basis of object representations, focusing on medial temporal lobe (MTL) structures, namely, perirhinal cortex, parahippocampal cortex, and hippocampus. I use what type of thing an object is, or more specifically, the broader category (e.g., “face” or “house”) or …