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2022

Metabolism

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Role Of Fasting In Caloric Restriction Improved Glucose Tolerance, Makayla M. Dillon May 2022

Role Of Fasting In Caloric Restriction Improved Glucose Tolerance, Makayla M. Dillon

ETD Archive

The Caloric Restriction (CR) diet in mammals has been shown to increase longevity and prevent metabolic disorders. Some of the benefits of CR include improved glucose homeostasis, namely improvements in glucose tolerance. Mice on the CR diet have a 30% reduction in food provided, as well as a fasting period between meals as they are only fed once a day. Hence the benefits of CR stem from both fasting and reduced calorie intake. In this study, we investigated if the fasting component of CR is responsible for the benefits of this diet in improving glucose homeostasis. In particular, we used …