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Life Sciences

Doctoral Dissertations

Theses/Dissertations

2018

Obesity

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Interaction Of Titanium Dioxide Nanoparticles (Nps) With Food Components And Mechanistic Studies Of Adverse Effects Induced By Titanium Dioxide Nps, Xiaoqiong Cao Jul 2018

Interaction Of Titanium Dioxide Nanoparticles (Nps) With Food Components And Mechanistic Studies Of Adverse Effects Induced By Titanium Dioxide Nps, Xiaoqiong Cao

Doctoral Dissertations

Many food products contain engineered inorganic nanoparticles (NPs), such as titanium dioxide (TiO2) NPs as a part of food additive, due to both unintentional and intentional additions. There has been increasing concern about the health risks associated with foodborne inorganic NPs. However, the detailed understanding of the biological fate and potential adverse effects of foodborne TiO2 NPs is not available despite a limited number of published toxicity studies on TiO2 NPs. The purpose of this thesis was to characterize the interactions of TiO2 NPs and food components including dietary flavonoids and dietary proteins, …


A Living Model For Obesity And Aging Research: Caenorhabditis Elegans, Peiyi Shen Mar 2018

A Living Model For Obesity And Aging Research: Caenorhabditis Elegans, Peiyi Shen

Doctoral Dissertations

Caenorhabditis elegans (C. elegans) is a free-living nematode that has been extensively utilized as an animal model for the research involving aging and neurodegenerative diseases, like Alzheimer and Parkinson, etc. Compared with the traditional animal models, this nematode possesses many benefits, such as small body size, short lifespan, complete sequenced genome and more than 65% of the genes associated with human diseases. All these characteristics enable this organism to be an ideal living system for obesity and aging studies. Piceatannol is a natural stilbene with many beneficial effects, such as anti-oxidative, anti-inflammatory, anti-atherogenic activities, however, its role on …