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Brown And Beige Adipocytes: Effects Of Inflammation And Nutritional Intervention, Jiyoung Bae
Brown And Beige Adipocytes: Effects Of Inflammation And Nutritional Intervention, Jiyoung Bae
Doctoral Dissertations
Recent findings of brown adipocytes and brown-like or beige adipocytes, capable of dissipating energy as heat, in adult humans have promised new hope for obesity treatment and prevention. Understanding of the regulation of brown and beige adipocytes will provide novel strategies to reach the goal. Pattern recognition receptors (PRR) are responsible for inflammation in adipose tissue, which leads to adipose dysfunction and obesity associated chronic diseases. It has been shown that PRR activation induces inflammation, leading to insulin resistance in white adipocytes and white adipose tissue (WAT). However, the roles of PRR activation in brown adipocytes and brown adipose tissue …
Gestational Diabetes, Infant Feeding Practices, And Early Indicators Of Obesity Risk In A Sample Of Mother-Infant Dyads In The U.S., Kimberly N. Doughty
Gestational Diabetes, Infant Feeding Practices, And Early Indicators Of Obesity Risk In A Sample Of Mother-Infant Dyads In The U.S., Kimberly N. Doughty
Doctoral Dissertations
Research suggests that the trajectory to obesity and its associated metabolic disorders begins early in life. Prenatal exposure to maternal gestational diabetes mellitus (GDM) is associated with increased risk, while breastfeeding is associated with reduced risk. Breastfeeding may influence obesity risk by preventing rapid postnatal weight gain. Mothers with gestational diabetes may not breastfeed as intensely as healthy mothers, potentially exacerbating the risk to their infants. We conducted three distinct investigations related to gestational diabetes, breastfeeding, and infant weight gain. All used data from the U.S. Infant Feeding Practices Study II. Multivariate logistic regression was used to estimate associations between …
Effects Of Conjugated Linoleic Acid (Cla) On Skeletal Muscle Metabolism, Yoo Kim
Effects Of Conjugated Linoleic Acid (Cla) On Skeletal Muscle Metabolism, Yoo Kim
Doctoral Dissertations
Although it is well known that increased physical activity can help reduce incidences of obesity, physical activity can be influenced by complex issues, making it difficult to use universal means to control obesity. Recent discoveries of the effects of exercise at the cellular level opened up the unique opportunity to develop compounds with ‘exercise-like’ effects. In fact, CLA has been shown to promote voluntary activity and endurance capacity in mice. Thus, the purpose of these studies is to determine the mechanisms of conjugated linoleic acid on muscle metabolism via the modulation of biochemical events including mitochondrial biogenesis and the alternation …
The Investigation Of Rhodiola Crenulata Root Extract Effects On Obesity Associated Inflammation And The Antineoplastic Mechanism In Breast Cancer Cells, Lotfi M. Bassa
Doctoral Dissertations
Obesity and breast cancer are two disease models that directly affect the United States population, as more than 35% of the adult population is obese [8], and more than 200,000 new cases of breast cancer are diagnosed in the United States per year [34]. Several diseases are associated with obesity including, cardiovascular disease, insulin resistance, increased inflammation and increased cancer risk [9,10]. Therefore it essential to understand the risks associated with obesity as well as to investigate possible preventive and/or therapeutic treatment strategies. Rhodiola crenulata is a Tibetan plant that has been used in Eastern traditional medicine to relieve depression, …
Exploring Novel Environmental Link To Obesity: Role Of Parabens In Adipogenesis In Vitro And In Vivo, Pan Hu
Exploring Novel Environmental Link To Obesity: Role Of Parabens In Adipogenesis In Vitro And In Vivo, Pan Hu
Doctoral Dissertations
Parabens are a group of alkyl esters of p-hydroxybenzoic acid that include methylparaben, ethylparaben, propylparaben, butylparaben, and benzylparaben. Paraben esters and their salts are widely used as preservatives in cosmetics, toiletries, food, and pharmaceuticals. Humans are exposed to parabens through the use of such products from dermal contact, ingestion, and inhalation. The extent of the exposure is reflected by the frequent detection of these compounds in urine samples in the general population. Moreover, parabens have been detected in human serum, milk, placental tissues and breast tumor tissues. Parabens have been shown to preserve estrogenic/antiandrogenic effects, and can activate peroxisome proliferator-activated …