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The Role Of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis, Fei Han
The Role Of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis, Fei Han
Dissertations & Theses (Open Access)
AMPK plays a central role in controlling cellular and whole body energy level. Increasing studies have also discovered the diverse function of AMPK in cancer, such as autophagy and mitochondria biogenesis. However, how AMPK promotes cancer progression is still not clear. Here, we show that AMPK is essential for EGF-induced Akt activation, Glut1 expression, and glucose uptake. AMPK is also required for various stresses induced Akt activation and promote cell survival, including hypoxia and glucose deprivation. In addition, we found glucose deprivation-induced VEGF expression and secretion is also depend on AMPK, which may contribute to angiogenesis of surrounding endothelial cell …