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Functional Regulation Of Yap By Aurora A Kinase In Triple-Negative Breast Cancer, Shih-Shin Chang
Functional Regulation Of Yap By Aurora A Kinase In Triple-Negative Breast Cancer, Shih-Shin Chang
Dissertations & Theses (Open Access)
The Yes-associated protein (YAP) is an effector that transduces the output of the Hippo pathway to transcriptional modulation. Considering the role of YAP in cancers, this protein has emerged as a key node in malignancy development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. Moreover, aberrant expression of YAP and Aurora A signaling is highly correlated with triple-negative breast cancer (TNBC). We herein provide evidence to establish the …