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Anticancer Properties Of Research-Grade Hydrastis Canadensis (Goldenseal) And Characterization Of Its Effect On The Mdr1-Encoded Phosphoglycoprotein Efflux Pump, Sara Garrett

All Theses

Multiple drug resistance (MDR) in tumors, observed both in vivo and in vitro, is generally attributed to efflux-mediated reduced drug accumulation via mdr1/P-gp. Notoriously chemoresistant colorectal cancers exhibit the highest P-gp expression, account for 9% of all cancer deaths, and are the third most common cancer in men and women. P-gp, a 170kDa protein, contains twelve transmembrane segments with two ATP-binding domains used to extrude intracellular compounds of broad specificity against a concentration gradient. Studies concerning natural health products are becoming more prevalent in the search for safe anti-P-gp remedies and Hydrastis canadensis (goldenseal) was studied for its anti-cancer properties. …