Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
The Role Of Connexin And Pannexin Large-Pore Channels In Hearing, Julia Abitbol
The Role Of Connexin And Pannexin Large-Pore Channels In Hearing, Julia Abitbol
Electronic Thesis and Dissertation Repository
Connexin and pannexin large-pore channels allow the regulated passage of small molecules at sites of cell-cell contacts, and from the cytosol to the extracellular milieu, respectively. Since it has been known for many years that Cx26 and Cx30 gap junction proteins are crucial in hearing we propose that Cx43 might also be important in hearing. Here we used two different genetically modified mouse lines that contain systemic Cx43 gene mutations that reduces gap junctional intercellular communication (GJIC) to examine whether Cx43 is also important for proper hearing function. Furthermore, since pannexins have also been postulated to be involved in auditory …
Multisensory Responses In Primary Auditory Cortex Of The Cat, Catherine Boucher
Multisensory Responses In Primary Auditory Cortex Of The Cat, Catherine Boucher
Electronic Thesis and Dissertation Repository
Core auditory cortex of the cat is comprised of primary auditory cortex (A1) and the anterior auditory field (AAF). Neurons in both fields respond strongly to acoustic stimuli and are tonotopically organized. In hearing animals, a small number of cells in AAF respond to tactile stimulation. However, it is unclear if multisensory input influences responses in A1. In this study, multisensory stimuli were developed by pairing a pure tone stimulus with a flash stimulus at various stimulus onset asynchronies. A linear multielectrode array recorded multi-unit activity in A1 across cortical layers. We identified unisensory auditory, unisensory visual, bimodal, and subthreshold …