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The Effect Of Anoxia On Mitochondrial Function In A Hibernator (Ictidomys Tridecemlineatus), Leah Hayward
The Effect Of Anoxia On Mitochondrial Function In A Hibernator (Ictidomys Tridecemlineatus), Leah Hayward
Electronic Thesis and Dissertation Repository
Hibernation protects mammalian tissues against ischemia-reperfusion injury, but the underlying biochemical mechanisms are unknown. I hypothesized that the mechanisms allowing for mitochondrial metabolic flexibility during hibernation permit anoxia tolerance and contribute to tissue ischemia-reperfusion tolerance. I assessed mitochondrial performance before and after five minutes of anoxia in liver mitochondria isolated from thirteen-lined ground squirrels. I compared this anoxia effect among animals that were summer active (SA), or during hibernation (in torpor or interbout euthermia; IBE). Anoxia decreased state 3 respiration in all groups, but mitochondria isolated from torpid squirrels were least affected; these decreases paralleled decreased activity of electron transport …
Circannual Patterns Of Adipose Tissue Characteristics In A Hibernator, The Thirteen-Lined Ground Squirrel (Ictidomys Tridecemlineatus), Amanda Maccannell
Circannual Patterns Of Adipose Tissue Characteristics In A Hibernator, The Thirteen-Lined Ground Squirrel (Ictidomys Tridecemlineatus), Amanda Maccannell
Electronic Thesis and Dissertation Repository
Obligate hibernators express circannual patterns of body mass and hibernation, which persist under constant laboratory conditions. I hypothesized that in the 13-lined ground squirrel (Ictidomys tridecemlineatus) thermogenic brown adipose tissue (BAT) and lipid storing white adipose tissue (WAT) volume would follow a circannual pattern. I housed animals at either 25°C (thermoneutral) or 5°C with 12h L:12h D photoperiods for an entire year. I determined volume and water-fat ratio of WAT and BAT using magnetic resonance imaging (MRI). BAT volume follows a circannual pattern in both conditions, increasing prior to winter, decreasing in late winter with no change in …