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Life Sciences

Western University

Theses/Dissertations

2014

FMRI

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Characterizing Persistent Developmental Dyscalculia: A Cognitive Neuroscience Approach, Stephanie D. Bugden Dec 2014

Characterizing Persistent Developmental Dyscalculia: A Cognitive Neuroscience Approach, Stephanie D. Bugden

Electronic Thesis and Dissertation Repository

Developmental dyscalculia (DD) is a specific learning disorder of calculation abilities. In the present thesis I report a series behavioural and functional neuroimaging studies to further elucidate the core numerical deficits underlying DD. I recruited a sample of children with DD who demonstrated persistent impairments in arithmetic. In Chapter 2, to validate the selection criteria, I compared the performance of children with and without persistent DD on a test of numerical magnitude processing. The data showed that only children with persistent DD presented with deficits in numerical magnitude processing, while those with inconsistent DD perform at the level of age-matched …


Advances In Image Acquisition And Filtering For Mri Neuroimaging At 7 Tesla, Andrew T. Curtis Sep 2014

Advances In Image Acquisition And Filtering For Mri Neuroimaging At 7 Tesla, Andrew T. Curtis

Electronic Thesis and Dissertation Repository

Performing magnetic resonance imaging at high magnetic field strength promises many improvements over low fields that are of direct benefit in functional neuroimaging. This includes the possibility of improved signal-to-noise levels, and increased BOLD functional contrast and spatial specificity. However, human MRI at 7T and above suffers from unique engineering challenges that limit the achievable gains. In this thesis, three technological developments are introduced, all of which address separate issues associated with functional magnetic resonance neuroimaging at very high magnetic field strengths.

First, the image homogeneity problem is addressed by investigating methods of RF shimming — modifying the excitation portion …