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Neurodevelopmental Consequences Of Prenatal Alcohol Exposure: Behavioural And Transcriptomic Alterations In A Mouse Model, Katarzyna Mantha

Electronic Thesis and Dissertation Repository

Fetal Alcohol Spectrum Disorder (FASD) is an umbrella term referring to a range of physical, behavioural, and cognitive deficits resulting from prenatal alcohol exposure. The resulting abnormalities are heterogeneous and often attributed to timing and dosage of alcohol exposure. However, the specific effects of developmental timing are not well-known.

This research used C57BL/6J (B6) as an animal model for early (human trimester one) and mid-gestation (human trimester two) alcohol exposure. Pregnant B6 mice were injected with 2.5 g/kg ethanol on gestational day (GD) 8 and 11 (trimester one equivalent), or on GD 14 and 16 (trimester two equivalent). Resulting pups …