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Taking Tone Into Account: Cognitive Neuroscientific Investigations Of Mandarin Chinese Spoken Word Processing, Jeffrey G. Malins
Taking Tone Into Account: Cognitive Neuroscientific Investigations Of Mandarin Chinese Spoken Word Processing, Jeffrey G. Malins
Electronic Thesis and Dissertation Repository
To date, theories of how humans recognize spoken words have yet to account for tonal languages such as Mandarin Chinese. One reason for this is that we know relatively little about how native speakers of tonal languages process spoken words in the brain. This dissertation addresses this problem by examining Mandarin spoken word processing in both adult native speakers and typically developing children. In adults, functional magnetic resonance imaging (fMRI) was used to assess the extent to which the brain regions involved in processing tonal information are distinct from those involved in vowel processing (Chapter 2), while event related potentials …
Developmental Characterization Of Tissue Inhibitor Of Metalloproteinase Domain Functions In Xenopus Laevis, Michelle A. Nieuwesteeg
Developmental Characterization Of Tissue Inhibitor Of Metalloproteinase Domain Functions In Xenopus Laevis, Michelle A. Nieuwesteeg
Electronic Thesis and Dissertation Repository
During development the extracellular matrix is cleaved and remodeled to facilitate the large-scale cell rearrangements that are necessary for processes like gastrulation, neurulation, angiogenesis and organogenesis. ECM remodeling occurs primarily through secreted enzymes called matrix metalloproteinases (MMPs). Regulation of MMP activity is achieved through the tissue inhibitor of metalloproteinases (TIMPs), a small family of secreted proteins that bind MMPs in a 1:1 manner to inhibit their activity. Although TIMPs were originally characterized based on their MMP-inhibitory activities, in vitro studies have revealed that TIMPs are multifunctional proteins, with structurally and functionally distinct N- and C-terminal domains. TIMP N-terminal domains bind …