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Microvascular Consequences Of Engineered Nanomaterial Inhalation Exposure And Subsequent Reproductive Outcomes, Krista Lee Garner
Microvascular Consequences Of Engineered Nanomaterial Inhalation Exposure And Subsequent Reproductive Outcomes, Krista Lee Garner
Graduate Theses, Dissertations, and Problem Reports
Nano-titanium dioxide (nano-TiO2) is a commonly utilized engineered nanomaterial found ubiquitously in consumer products. While benefits of ENM utilization in are undeniable, nanoparticle inhalation has been linked to cardiovascular consequences and altered microvascular responses. Given these outcomes, it is important to explore vulnerable timepoints, such as gestation, as robust vascular adaptations are essential for maternofetal health.
The first aim of this dissertation was to assess myogenic responsiveness following maternal nano-TiO2 inhalation. Fetal aortic responses were evaluated on gestational day (GD) 20 to assess how exposure may impact the F1 generation. Myogenic responsiveness within the uterine radial arteries …