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Intravenous Administration Of Perfluorocarbon Emulsions As A Non-Recompression Therapy For Decompression Sickness, Cameron Smith
Intravenous Administration Of Perfluorocarbon Emulsions As A Non-Recompression Therapy For Decompression Sickness, Cameron Smith
Theses and Dissertations
Decompression sickness (DCS) results from a sudden decrease in ambient pressure leading to super-saturation of tissues with inert gas and subsequent bubble formation within both tissues and blood. Perfluorocarbons (PFC) are able to dissolve vast amounts of non-polar gases. The administration of intravenous (I.V.) PFC emulsions reduce both morbidity and mortality of DCS, but the mechanism of this protective effect has not yet been demonstrated. Juvenile Dorper cross sheep between 16 and 24 kg (n=31) were anaesthetized and instrumented for physiological monitoring, the administration of I.V. fluids and sampling of arterial and mixed venous blood. Animals were placed in a …