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Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons, Trevor J. Fish
Dna Methylation In Lung Tissues Of Mouse Offspring Exposed In Utero To Polycyclic Aromatic Hydrocarbons, Trevor J. Fish
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
Polycyclic aromatic hydrocarbons (PAHs) comprise an important class of environmental pollutants that are known to cause lung cancer in animals and suspected lung carcinogens in humans. PAHs are also known to cause cancer in offspring when provided to a pregnant mouse. Some evidence from cell-based studies points to PAHs as modulators of the epigenome, that is modifications to DNA structure that control the expression of genes. Inappropriate changes to the epigenome and consequently expression of cancer-critical genes are often characteristic of cancer cells. The objective of this thesis research was to determine the impact of transplacental exposure to two model …
Dna Methylation Analysis Of Lin28a & Hand1 In Electrostimulated Genetically Unmodified Porcine Fibroblast Cells Grown In Vitro, Sara E. Calicchia
Dna Methylation Analysis Of Lin28a & Hand1 In Electrostimulated Genetically Unmodified Porcine Fibroblast Cells Grown In Vitro, Sara E. Calicchia
Undergraduate Honors Capstone Projects
Pluripotent (undifferentiated) cells are important for their applications in regenerative medicine. However, gene-based nuclear reprogramming of adult somatic cells is a slow and inefficient process, and poses some risk to recipient patients. Therefore, a major goal within the field of stem cell biology is to find a way to accomplish adult somatic cell de-differentiation using small chemical modulators of gene expression or other non-genomic mechanisms. Pilot studies in our laboratory have suggested that cells exposed to silver ions generated by the passage of a weak electrical current through a silver wire show morphological and gene expression changes reminiscent of de-differentiation. …