Digital Commons Network^™

The Effects Of Phenylbutazone On A Strain Of Fibroblasts Cultivated In Vitro, Ann Weyrauch Bauermeister

University of the Pacific Theses and Dissertations

Phenylbutazone was first synthesized in 1946 by H. Stenzyl during his investigation on pyrazole and pyrazoline derivatives. Although these compounds had been studied during the previous fifty years, the pharmacological properties were only recently recognized. It has been used clinically since 1952.

Two other pharmaceutical agents of the pyrazole group are phenazone and amidopyrine; these were used as early as the nineteenth century. While phenazone and aminopyrine have basic properties, phenylbutazone exhibits distinctly acidic ones and is capable of forming salts with organic and inorganic bases.

In order to achieve a more basic understanding of how phenylbutazone produces effects, the …