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Induced Pluripotent Stem Cells As Tools For Disease Modelling And Drug Discovery In Alzheimer's Disease, Lezanne Ooi, Kuldip Sidhu, Anne Poljak, Greg Sutherland, Michael D. O'Connor, Perminder Sachdev, Gerald Munch

Faculty of Science - Papers (Archive)

Alzheimer’s disease (AD) is a progressive neurodegenerative brain disorder that leads to a progressive decline in a person’s memory and ability to communicate and carry out daily activities. The brain pathology in AD is characterized by extensive neuronal loss, particularly of cholinergic neurons, intracellular neurofibrillary tangles composed of the tau protein (NFTs) and extracellular deposition of plaques composed of β-amyloid (Aβ), a cleavage product of the amyloid precursor protein (APP). These two insoluble protein aggregates are accompanied by a chronic inflammatory response and extensive oxidative damage. Whereas dys-regulation of APP expression or processing appears to be important for the familial, …

Musculoskeletal And Estrogen Changes During The Adolescent Growth Spurt In Girls, Catherine Y. Wild, Julie R. Steele, Bridget J. Munro

Faculty of Health and Behavioural Sciences - Papers (Archive)

Introduction: The adolescent growth spurt is associated with rapid growth and hormonal changes, thought to contribute to the increased anterior cruciate ligament injury risk in girls. However, relatively little is known about these musculoskeletal and estrogen changes during the growth spurt in girls. Purpose: To investigate the longitudinal changes in estrogen as well as anterior knee laxity and lower limb strength and flexibility throughout the adolescent growth spurt in girls. Methods: Thirty-three healthy girls, age 10-13 yr, in Tanner stage II and 4-6 months from their peak height velocity were recruited. Participants were tested up to four times during the …

Translocation Of The Eastern Bristlebird 1: Radio-Tracking Of Post-Release Movements, David Bain, Kris French, Jack Baker, Jean Clarke

Faculty of Science - Papers (Archive)

Translocating birds to a new area of habitat to restore or supplement depleted populations may pose a significant threat to the translocated individuals. While for many species, translocated individuals appear to move larger distances than resident animals, species with poor dispersal capacity may be restricted in movements and translocation methods may need to accommodate differences in movements to ensure success. In this study, designed to provide insights to inform our broader programme of translocations in New South Wales, Australia, we investigated post-release movements in the endangered, semi-flightless Eastern Bristlebird (Dasyornis brachypterus). We predicted that movements would be minimal, with few …

Australian Adolescents' Compliance With Sun Protection Behaviours During Summer: The Importance Of The School Context, Melinda Williams, Sandra C. Jones, Peter Caputi, Donald Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Adolescents exhibit significantly lower sun protection behaviours than adults in Australia. While many studies have assessed the sun protection behaviours of adolescents during summer, few studies have explored the differences in sun protection behaviours of adolescents across key contexts relevant to adolescents during summer—notably school time, weekends and school holidays. Greater understanding of differences in behaviours across these contexts provides more detailed explanations of the nature of adolescent ultraviolet exposure and thereby facilitates improved targeting of interventions for this segment whose behaviour is considered hard to change. In this study, we explore the differences in self-reported, habitual, sun protection behaviours …

Fish Consumption And Chd Mortality: An Updated Meta-Analysis Of Seventeen Cohort Studies, Jusheng Zheng, Tao Huang, Yinghua Yu, Xiaojie Hu, Bin Yang, Duo Li

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective Results of studies on fish consumption and CHD mortality are inconsistent. The present updated meta-analysis was conducted to investigate the up-to-date pooling effects. Design A random-effects model was used to pool the risk estimates. Generalized least-squares regression and restricted cubic splines were used to assess the possible dose–response relationship. Subgroup analyses were conducted to examine the sources of heterogeneity. Setting PubMed and ISI Web of Science databases up to September 2010 were searched and secondary referencing qualified for inclusion in the study. Subjects Seventeen cohorts with 315 812 participants and average follow-up period of 15·9 years were identified. Results …

Reflection Impulsivity In Adolescent Cannabis Users: A Comparison With Alcohol-Using And Non-Substance-Using Adolescents, Nadia Solowij, Katy A. Jones, Megan E. Rozman, Sasha M. Davis, Joseph Ciarrochi, Patrick C. L Heaven, Nicole Pesa, Dan I. Lubman, Murat Yucel

Faculty of Health and Behavioural Sciences - Papers (Archive)

Rationale Reflection impulsivity-a failure to gather and evaluate information before making a decision-is a critical component of risk-taking and substance use behaviours, which are highly prevalent during adolescence. Objectives and methods The Information Sampling Test was used to assess reflection impulsivity in 175 adolescents (mean age 18.3, range 16.5-20; 55% female)-48 cannabis users (2.3 years use, 10.8 days/month), 65 alcohol users, and 62 non-substance-using controls-recruited from a longitudinal cohort and from the general community and matched for education and IQ. Cannabis and alcohol users were matched on levels of alcohol consumption. Results Cannabis users sampled to the lowest degree of …

Online Advertising: Examining The Content And Messages Within Websites Targeted At Children, Lisa Kervin, Sandra C. Jones, Jessica Mantei

Faculty of Health and Behavioural Sciences - Papers (Archive)

It is recognised that from a young age children spend considerable portions of their leisure time on the Internet. In Australia a number of child-targeted magazines have associated websites, which have high and ever-increasing readership. We do not yet know the impact of this medium upon children. Overt advertising is evident on webpages, but so too are hidden advertisements in the written text, images and games. This material usually does not comply with existing broadcasting codes of practice for mainstream advertising. This article examines the instances of overt and covert advertisements for food within three websites monitored over a 12-month …

Using Interviews And Peer Pairs To Better Understand How School Environments Affect Young Children's Playground Physical Activity Levels: A Qualitative Study, Anne-Maree Parrish, Heather Yeatman, Donald Iverson, Ken Russell

Faculty of Health and Behavioural Sciences - Papers (Archive)

School break times provide a daily opportunity for children to be active; however, research indicates this time is underutilized. Reasons for low children’s playground activity levels have primarily focused on physical barriers. This research aimed to contribute to physical environmental findings affecting children’s playground physical activity levels by identifying additional variables through the interview process. Thirteen public schools were included in the sample (total 2946 children). Physical activity and environmental data were collected over 3 days. Environmental variables were manually assessed at each of the 13 schools. Observational data were used to determine which three schools were the most and …

Measuring Women's Beliefs About Glass Ceilings: Development Of The Career Pathways Survey, Paul Smith, Nadia Crittenden, Peter Caputi

Faculty of Health and Behavioural Sciences - Papers (Archive)

Purpose - The purpose of this study is to develop a new measure called the Career Pathways Survey (CPS) which allows quantitative comparisons of women's beliefs about glass ceilings. Design/methodology/approach - A 34-item version of the CPS was completed by 243 women from all levels of management, mostly in Australia. An expanded 38-item CPS was administered to another sample of women (N = 307). Findings - Analyses of data from both studies yielded a four factor model of attitudes to glass ceilings: resilience, acceptance, resignation and denial. The factors demonstrated good internal consistency. Practical implications - The CPS allows a …

The Effect Of Dairy Consumption On Blood Pressure In Mid-Childhood: Caps Cohort Study, A M. Rangan, V L. Flood, G Denyer, J G. Ayer, K L. Webb, G B. Marks, D S. Celermajer, Tim Gill

Faculty of Health and Behavioural Sciences - Papers (Archive)

Background/objectives: It has been postulated that higher dairy consumption may affect blood pressure regulation. The aim of this study was to examine the association between dairy consumption and blood pressure in mid-childhood. Methods: Subjects (n=335) were participants of a birth cohort at high risk of asthma withinformation on diet at 18 months and blood pressure at 8 years. Multivariate analyses were used to assess the association of dairy consumption (serves) and micronutrient intakes (mg) at 18 m with blood pressure at 8 y. In a subgroup of children (n=201), dietary intake was measured at age 18 m and 9 y …

Comparing Attitudes To Fish Consumption Between Clinical Trial Participants And Non-Trial Individuals, Elizabeth P. Neale, Deborah Nolan-Clark, Yasmine C. Probst, Marijka J. Batterham, Linda C. Tapsell

Faculty of Health and Behavioural Sciences - Papers (Archive)

Aim: The study aims to investigate attitudes and perceptions influencing fish consumption in a sample of clinical trial participants and compare these perceptions to those expressed by a sample of adults not involved in the trial. Methods: Six semi-structured focus groups were conducted; three with participants of a weight loss trial which incorporated specific and general fish consumption advice (n = 15) and three with nontrial participants from the same study population (n = 14). All data were recorded digitally and transcribed verbatim by the moderator. Data analysis was carried out using NVivo (QSR International Pty Ltd, Melbourne, Victoria, Australia). …

Are Parents' Working Patterns Associated With Their Child's Sleep? An Analysis Of Dual-Parent Families In Australia, Christopher A. Magee, Peter Caputi, Don C. Iverson

Faculty of Health and Behavioural Sciences - Papers (Archive)

Insufficient sleep in children predicts emotional and behavioral problems, poorer school performance, and health problems. Child sleep durations have declined in recent decades, suggesting a need to identify and understand predictors of short sleep. The present study investigated whether aspects of parental employment (i.e. parental work hours, and non-standard work hours) were associated with sleep in children. Data collected from 2477 children aged 6–7 years as part of the Longitudinal Study of Australian Children were used in this paper. Child sleep duration, bedtimes, and wake times were determined from parent self-report using time-use diaries. Parents completed a survey assessing their …

Comorbid Externalising Behaviour In Ad/Hd: Evidence For A Distinct Pathological Entity In Adolescence, Sharnel Perera, David Crewther, Rodney Croft, Hannah Keage, Daniel Hermens, C Richard Clark

Faculty of Health and Behavioural Sciences - Papers (Archive)

While the profiling of subtypes of Attention Deficit Hyperactivity Disorder (AD/HD) have been the subject of considerable scrutiny, both psychometrically and psychophysiologically, little attention has been paid to the effect of diagnoses comorbid with AD/HD on such profiles. This is despite the greater than 80% prevalence of comorbidity under the DSM-IV-TR diagnostic definitions. Here we investigate the event related potential (ERP) and psychometric profiles of Controls, AD/HD, and comorbid AD/HD (particularly AD/HD+ODD/CD) groups on six neurocognitive tasks thought to probe the constructs of selective and sustained attention, response inhibition and executive function. Data from 29 parameters extracted from a child …

How Are Women's Glass Ceiling Beliefs Related To Career Success?, Paul Smith, Peter Caputi, Nadia Crittenden

Faculty of Health and Behavioural Sciences - Papers (Archive)

Purpose – The purpose of this study is to test the concurrent criterion validity of a new measure, the Career Pathways Survey (CPS) by exploring how women’s glass ceiling beliefs are related to five major indicators of subjective career success: career satisfaction, happiness, psychological wellbeing, physical health and work engagement (WE). Design/methodology/approach – Data from a cross-sectional study of 258 women working in Australian organizations were analyzed. The participants completed the CPS and measures of subjective career success. The CPS assesses four sets of beliefs about glass ceilings: denial, resilience, acceptance and resignation. Findings – Regression analyses showed denial was …

Validation Of The Differentiated Transformational Leadership Inventory As A Measure Of Coach Leadership In Youth Soccer, Stewart A. Vella, Lindsay G. Oades, Trevor P. Crowe

Faculty of Health and Behavioural Sciences - Papers (Archive)

This paper describes the validation of The Differentiated Transformational Leadership Inventory (DTLI) within a participation youth sports context. Three hundred and twenty-two athletes aged between 11 and 18 years completed the DTLI. Using a confirmatory factor analysis, the DTLI yielded an underlying factor structure that fell short of cut-off criteria for adjudging model fit. Subsequent theory-driven changes were made to the DTLI by removing the 'high performance expectations' subscale. Further data-driven changes were also made on the basis of high item-factor cross-loadings. The revised version of the DTLI was subjected to confirmatory factor analysis and proved to be a good …

Branded Food References In Children's Magazines: 'Advertisements' Are The Tip Of The Iceberg, Sandra C. Jones, Parri Gregory, Lisa K. Kervin

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective: While children's magazines 'blur the lines' between editorial content and advertising, this medium has escaped the calls for government restrictions that are currently associated with food advertisements aired during children's television programming. The aim of this study was to address significant gaps in the evidence base in relation to commercial food messages in children's magazines by systematically investigating the nature and extent of food advertising and promotions over a 12-month period. Method: All issues of Australian children's magazines published in the calendar year 2009 were examined for references to foods or beverages. Results: Approximately 16% of the 1678 food …

Relationship Between Breast-Feeding And Adiposity In Infants And Pre-School Children, Bamini Gopinath, Indhu Subramanian, Victoria M. Flood, Louise A. Baur, Natalie Pfund, George Burlutsky, Paul Mitchell

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objectives: We aimed to establish associations of duration of breast-feeding with mean BMI and waist circumference, as well as the likelihood of being overweight/ obese, during early childhood. Design: Cross-sectional, population-based study. Height, weight and waist circumference were measured and BMI calculated. Interviewer-administered questionnaire determined whether the child was ever breast-fed and the duration of breast-feeding. Setting: Sydney, Australia. Subjects: Infants and pre-school children (n 2092) aged 1-6 years were examined in the Sydney Paediatric Eye Disease Study during 2007-2009. Results: Of the children aged 1-6 years, 1270 had been breast-fed compared with 822 who were never breast-fed. After multivariable …

Dissociation Mediates The Relationship Between Childhood Trauma And Hallucination-Proneness., F Varese, E Barkus, R P. Bentall

Faculty of Health and Behavioural Sciences - Papers (Archive)

BACKGROUND: It has been proposed that the relationship between childhood trauma and hallucinations can be explained by dissociative processes. The present study examined whether the effect of childhood trauma on hallucination-proneness is mediated by dissociative tendencies. In addition, the influence of dissociative symptoms on a cognitive process believed to underlie hallucinatory experiences (i.e. reality discrimination; the capacity to discriminate between internal and external cognitive events) was also investigated.MethodPatients with schizophrenia spectrum disorders (n=45) and healthy controls (with no history of hallucinations; n=20) completed questionnaire measures of hallucination-proneness, dissociative tendencies and childhood trauma, as well as performing an auditory signal detection …

Predicting Clinically Signficant Change In An Inpatient Program For People With Severe Mental Illness, Talia Gonda, Frank P. Deane, Ganapathi A. Murugesan

Faculty of Health and Behavioural Sciences - Papers (Archive)

Objective: The first aim of this study was to assess the proportion of patients who achieved reliable and clinically significant change over the course of treatment in an inpatient psychosocial rehabilitation program. The second aim was to determine whether age, gender, length of stay, and diagnosis and co-morbid diagnosis predicted those who were classified as improved or not improved, using clinical significance criteria. Method: Three hundred and thirty-seven patients from inpatient units at Bloomfield Hospital, Orange, New South Wales, Australia were assessed at admission, 3-month reviews and discharge using the expanded Brief Psychiatric Rating Scale, the Health of the Nation …

Functional Connectivity In Brain Networks Underlying Cognitive Control In Chronic Cannabis Users, Ian H. Harding, Nadia Solowij, Ben J. Harrison, Michael Takagi, Valentina Lorenzetti, Dan I. Lubman, Marc L. Seal, Christos Pantelis, Murat Yucel

Faculty of Health and Behavioural Sciences - Papers (Archive)

The long-term effect of regular cannabis use on brain function underlying cognitive control remains equivocal. Cognitive control abilities are thought to have a major role in everyday functioning, and their dysfunction has been implicated in the maintenance of maladaptive drug-taking patterns. In this study, the Multi-Source Interference Task was employed alongside functional magnetic resonance imaging and psychophysiological interaction methods to investigate functional interactions between brain regions underlying cognitive control. Current cannabis users with a history of greater than 10 years of daily or near-daily cannabis smoking (n=21) were compared with age, gender, and IQ-matched non-using controls (n=21). No differences in …

Commentary: Career Progress Relative To Opportunity: How Many Papers Is A Baby 'Worth'?, Natascha Klocker, Danielle Drozdzewski

Faculty of Science - Papers (Archive)

How many papers is a baby ‘worth’? We were prompted to ask this provocative question by recent experiences, working on appointment committees and writing research grants in Australia, where provisions to quantify research track-records ‘relative to opportunity’ call for applicants to explain how fl uctuations in their publication outputs have been impacted by ‘career interruptions’ such as childbearing. In this age of the increasingly neoliberal university—where every activity, output, and impact is audited (Castree, 2000; 2006)—our commentary seeks to question how decision makers account (or not) for the career impacts of having children.

Living Together But Apart: Material Geographies Of Everyday Sustainability In Extended Family Households, Natascha Klocker, Chris Gibson, Erin Borger

Faculty of Science - Papers (Archive)

In the Industrialized West, ageing populations and cultural diversity-combined with rising property prices and extensive years spent in education-have been recognized as diverse factors driving increases in extended family living. At the same time, there is growing awareness that household size is inversely related to per capita resource consumption patterns, and that urgent problems of environmental sustainability are negotiated, on a day-to-day basis (and often unconsciously), at the household level. This paper explores the sustainability implications of everyday decisions to fashion, consume, and share resources around the home, through the lens of extended family households. Through interviews with extended family …

Driving, Cities And Changing Climates, Gordon R. Waitt, Theresa Harada

Faculty of Science - Papers (Archive)

The relevance of cars in relation to changing climates seems indisputable: scientific evidence points out the significant contribution of cars globally in causing greenhouse gas emissions. Despite higher levels of general public understanding and concern about climate change, this has not generally resulted in decreased car use. This paper outlines how a spatial perspective drawing on a cultural economy approach may provide insights into the paradox of the environmental ‘value action gap’ by focusing on suburban belongings, passions and anticipations derived from driving. Drawing on insights from Burraneer Bay, an affluent Sydney suburb, the paper illustrates how habituated and embodied …

Book Review - Women In Leadership: Contextual Dynamics And Boundaries, Christine Eriksen

Faculty of Science - Papers (Archive)

Leadership scenarios and paradoxes - past, present and future - form the basis of Karin Klenke's analysis of women in leadership. The book sets out to explore the paradoxical nature of women's leadership in male-dominated contexts, paradoxes women leaders are confronted with, as well as the paradox of change versus the persistence of the status quo. Contexts with a 'paradoxical nature'- temporally and spatially - are at the forefront. These 'contexts' for women's leadership range from remarkable female leaders, today and historically, in politics, organisational structures, information technology (IT), the media, sports, the military, religion and spirituality, science, higher education …

The Awkward Spaces Of Fathering [Book Review], Ben Gallan

Faculty of Science - Papers (Archive)

This review starts with PiriWeepu, the All Black and rugby world cup winner.An image depictingWeepu bottle-feeding his child was removed from a national anti-smoking advertisement in early 2012.What could be wrong with this tender moment between father and daughter? The image raised controversy because it conflicted with carefully scripted advertising campaigns promoting breastfeeding.

The First Climate Refugees? Contesting Global Narratives Of Climate Change In Tuvalu, Carol Farbotko, Heather Lazrus

Faculty of Science - Papers (Archive)

Climate change effects such as sea-level rise are almost certain. What these outcomes mean for different populations, however, is far less certain. Climate change is both a narrative and material phenomenon. In so being, understanding climate change requires broad conceptualisations that incorporate multiple voices and recognise the agency of vulnerable populations. In climate change discourse, climate mobility is often characterised as the production of 'refugees', with a tendency to discount long histories of ordinary mobility among affected populations. The case of Tuvalu in the Pacific juxtaposes migration as everyday practice with climate refugee narratives. This climate-exposed population is being problematically …

Conducting Sensitive Research In The Present And Past Tense: Recounting The Stories Of Current And Former Child Domestic Workers, Natascha Klocker

Faculty of Science - Papers (Archive)

In recent years, scholarship on children's work has increasingly incorporated the perspectives of working children. Although laudable, this shift toward children's inclusion in research has concentrated on those employed at the time of data collection. Former child workers have largely been overlooked as a source of information. This paper reflects on research conducted with current and former child domestic workers in Tanzania. The child domestic working experiences reported by those two groups diverged markedly: those who had already ceased employment reported far higher rates of dissatisfaction with child domestic work, and far more experiences of exploitation and abuse, than those …

The Atlas Of Women In The World [Book Review], Christine Eriksen

Faculty of Science - Papers (Archive)

The Atlas ofWomen in theWorld is a resourceful book that instantly drew me in with its interesting choice of topics, vibrant colours and magnificent graphs. Joni Seager - an internationally acclaimed feminist geographer - highlights in the introduction that gender equality has yet to be attained around the world as well as what has actually improved for women since the first edition of the atlas was published in 1986.

Clinical Dyslipidaemia Is Associated With Changes In The Lipid Composition And Inflammatory Properties Of Apolipoprotein-B-Containing Lipoproteins From Women With Type 2 Diabetes, M Ståhlman, T H. Pham, M Adiels, Todd Mitchell, Stephen J. Blanksby, B Fagerberg, K Ekross, J Boren

Faculty of Science - Papers (Archive)

Aims/hypothesis The aim of this study was to use lipidomics to determine if the lipid composition of apolipoprotein-Bcontaining lipoproteins is modified by dyslipidaemia in type 2 diabetes and if any of the identified changes potentially have biological relevance in the pathophysiology of type 2 diabetes.

Methods VLDL and LDL from normolipidaemic and dyslipidaemic type 2 diabetic women and controls were isolated and quantified with HPLC and mass spectrometry. A detailed molecular characterisation of VLDL triacylglycerols (TAG) was also performed using the novel ozone-induced dissociation method, which allowed us to distinguish vaccenic acid (C18:1 n-7) from oleic acid (C18:1 n-9) in …

A Hangover And A One-Night Stand: Alcohol And Risky Sexual Behaviour Among Female Students At An Australian University, Heidi Gilchrist, Kylie Smith, Christopher A. Magee, Sandra Jones

Faculty of Health and Behavioural Sciences - Papers (Archive)

There is a growing body of research in Australia exploring the alcohol consumption behaviours of young people and the attendant health and social risks associated with excessive use of alcohol (Chikritzhs et al. 2003; Mancina-Pena & Tyson 2007). A number of studies from countries such as the United States and New Zealand indicate that university students tend to drink at riskier levels than the broader population (see for example Wechsler et al. 1994; Kypri, Stephenson & Langley 2005; Wechsler & Nelson 2008). Data from Australia are limited, although the few studies that have been conducted suggest that Australian university students …