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The Influence Of Prenatal Stress On Behaviors Associated With Schizophrenia And Autism Spectrum Disorder., Harold Bauerle
The Influence Of Prenatal Stress On Behaviors Associated With Schizophrenia And Autism Spectrum Disorder., Harold Bauerle
Graduate College Dissertations and Theses
Disorders such as schizophrenia (SCZ) and austism spectrum disorder (ASD) have long been associated with prenatal stress. In these three experiments, we attempted to correlate stress during gestation with behaviors considered to have good facial validity with SCZ and ASD in both juvenile and adult animals. To differentiate the effects of prenatal stress (PS) from the effects of early life stress due to a dam's behavior (MS), half of offspring animals were cross fostered to dams treated in the alternative condition as the offspring during pregnancy in experiments 2 and 3. In experiment 1, but not in 2 or 3, …
Gene Expression Noise In Stress Response As A Survival Strategy In Fluctuating Environments, Javier Garcia-Bernardo
Gene Expression Noise In Stress Response As A Survival Strategy In Fluctuating Environments, Javier Garcia-Bernardo
Graduate College Dissertations and Theses
Populations of cells live in uncertain environments, where they encounter large variations in nutrients, oxygen and toxic compounds. In the fluctuating environment, cells can sense their surroundings and express proteins to protect themselves against harmful substances. However, if the stressor appears infrequently or abruptly, sensing can be too costly or too slow, and cells cannot rely solely on it. To hedge against the sudden appearance of a stressor, cell populations can also rely on phenotypic diversification through bet-hedging. In bet-hedging, cells exploit noise in gene expression or use multistable genetic networks to produce an heterogeneous distribution of resistance-conferring protein levels. …