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Life Sciences

University of Tennessee, Knoxville

Theses/Dissertations

2014

Hepatitis A virus

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Control Of Emerging Foodborne Viruses Using Cranberry Extracts And Chemical Sanitizers, Snigdha Nitin Sewlikar Dec 2014

Control Of Emerging Foodborne Viruses Using Cranberry Extracts And Chemical Sanitizers, Snigdha Nitin Sewlikar

Masters Theses

Human norovirus (HNoV), hepatitis A virus (HAV) and Aichi virus (AiV) outbreaks that cause severe foodborne disease are on the rise globally. Strategies to prevent and mitigate the spread of these viral infections need to be investigated. HNoV, HAV and AiV are known to be resistant to most of the conventionally used chemical inactivation methods. Cranberry juice (CJ) and cranberry proanthocyanidins (C-PAC) have demonstrated antimicrobial and anti-inflammatory properties. CJ and C-PAC have been shown to exhibit antiviral activities against HNoV surrogates, feline calicivirus (FCV-F9) and murine norovirus (MNV-1) at room temperature. Hence, the objectives of this research were (1) To …


Thermal Inactivation Of Human Norovirus Surrogates And Hepatitis A Virus In Foods, Hayriye Bozkurt Cekmer May 2014

Thermal Inactivation Of Human Norovirus Surrogates And Hepatitis A Virus In Foods, Hayriye Bozkurt Cekmer

Doctoral Dissertations

Foodborne enteric viruses are the leading cause of gastroenteritis in humans. In particular, human noroviruses and hepatitis A virus (HAV) are the most important foodborne viral pathogens with regard to the number of outbreaks and people affected. Therefore, studies are needed to bridge existing data gaps and determine appropriate parameters for thermal inactivation methods for human norovirus and hepatitis A virus. Due to the absence of appropriate cell culture systems to propagate these viruses, cultivable surrogates (feline calicivirus, FCV-F9 and murine norovirus, MNV-1) are commonly used based on the assumption that they can mimic the viruses they represent. The objectives …