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Framework For The Evaluation Of Perturbations In The Systems Biology Landscape And Inter-Sample Similarity From Transcriptomic Datasets — A Digital Twin Perspective, Mariah Marie Hoffman
Framework For The Evaluation Of Perturbations In The Systems Biology Landscape And Inter-Sample Similarity From Transcriptomic Datasets — A Digital Twin Perspective, Mariah Marie Hoffman
Dissertations and Theses
One approach to interrogating the complexities of human systems in their well-regulated and dysregulated states is through the use of digital twins. Digital twins are virtual representations of physical systems that are descriptive of an individual's state of health, an object fundamentally related to precision medicine. A key element for building a functional digital twin type for a disease or predicting the therapeutic efficacy of a potential treatment is harmonized, machine-parsable domain knowledge. Hypothesis-driven investigations are the gold standard for representing subsystems, but their results encompass a limited knowledge of the full biosystem. Multi-omics data is one rich source of …
Impacts Of Environmental And Anthropogenic Stressors On Amphibian Welfare, Diversity, And Distribution In The Upper Missouri River Basin, Kaitlyn Campbell
Impacts Of Environmental And Anthropogenic Stressors On Amphibian Welfare, Diversity, And Distribution In The Upper Missouri River Basin, Kaitlyn Campbell
Dissertations and Theses
Climate change and anthropogenic stressors have contributed to rapid declines among various taxonomic groups; however, amphibian declines have been particularly intense and primarily stemmed from warming temperatures, habitat loss, exposure to contaminants, disease, and their subsequent interactions. Several climate mitigation strategies, like Bioenergy with Carbon Capture and Storage, have been proposed to alleviate the impact of rising temperatures; however, these proposals often fail to recognize and quantify the true impact on fauna, including changes in species distributions. To address this critical gap in knowledge, this research identified current amphibian distributions in the Upper Missouri River Basin and projected distribution changes …