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Local Translation And Focal Adhesions Are Dysregulated In Down Syndrome, Ashlyn Gotberg, Nikita Kirkise M.S., Kristy Welshhans Ph.D.
Local Translation And Focal Adhesions Are Dysregulated In Down Syndrome, Ashlyn Gotberg, Nikita Kirkise M.S., Kristy Welshhans Ph.D.
Senior Theses
During cellular migration, fibroblasts sense extracellular cues through membrane complexes at their leading edge and can respond to these cues via local translation. Local translation is the process in which mRNAs are transported to subcellular regions and translated in response to specific cues. There is evidence that local translation may be dysregulated in the neurodevelopmental disorder, Down syndrome, which is caused by the triplication of chromosome 21 and results in genome-wide dysregulation of protein expression. To determine if dysregulated local translation contributes to Down syndrome, we used three sets of primary fibroblasts from individuals with Down syndrome and apparently healthy …
Temperature Effects On Yield Of Ideal Wheat Cultivars, Jeffrey Jiang
Temperature Effects On Yield Of Ideal Wheat Cultivars, Jeffrey Jiang
Senior Theses
North American wheat growing areas show variation in many different factors, one of the most varied and important being temperature. Temperature is well established to correlate with yield. Given data from the Uniform Soft Red Winter Wheat Nursery and independently gathered data from government-owned weather stations, I explored possible correlations between temperature and wheat yield that can be extrapolated to areas that are not covered by the Uniform Soft Red Winter Wheat Nursery database. My analysis did not reveal strong correlations between temperature and growth, and in some cases, the sample size was too small. From this study, it was …