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Factors That Determine Spreading Depolarization Propagation In Brain Slices, Linday Selters
Factors That Determine Spreading Depolarization Propagation In Brain Slices, Linday Selters
Biomedical Engineering ETDs
In the US alone, more than 750,000 people had a stroke in 2017, more than 1.7 million reported a traumatic brain injury, and more than 9 million suffered from migraines with aura. While all three of these neurological conditions have vastly different causes and possible outcomes they all have a common phenomenon occurring within the brain. A wave that slowly propagates through grey matter, hitting neurons with a large burst of energy, opening them up to a flood of ions and silencing them for an extended period of time. These waves are known as spreading depolarizations (SD). Within well-nourished tissue, …