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Articles 1 - 7 of 7
Full-Text Articles in Entire DC Network
Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer
Alterations In Calcium Homeostasis And The Insulin-Like Growth Factor Signaling Pathway Induced By Carcinogenic Polycyclic And Halogenated Aromatic Hydrocarbons In Human Mammary Epithelial Cells, Stacey L. Tannheimer
Pharmaceutical Sciences ETDs
Breast cancer is a major health concern for women, with only a small percent of the risk factors currently identified. It has been estimated that environmental factors may contribute to up to 80% of breast cancer cases. Many environmental carcinogens, such as polycyclic and halogenated aromatic hydrocarbons (PAHs and HAHs), are proven mammary carcinogens in animal models. Therefore, these studies were conducted to elucidate potential roles of PAHs and HAHs in alterations in known signaling pathways in human mammary epithelial cells (HMEC). Carcinogenic PAHs have previously been shown to produce sustained alterations in the calcium (Ca2') homeostasis of lymphocytes Therefore, …
The Status Of The Amphibian Community In The Luquillo Experimental Forest, Lawrence L. Woolbright
The Status Of The Amphibian Community In The Luquillo Experimental Forest, Lawrence L. Woolbright
Long Term Ecological Research Network
No abstract provided.
Trade-Off-Invariant Rules For Evolutionarily Stable Life Histories, Eric Charnov
Trade-Off-Invariant Rules For Evolutionarily Stable Life Histories, Eric Charnov
Biology Faculty & Staff Publications
Optimization models have been widely and succesfully used in evolutionary ecology to predict the attributes of organisms. Most such models maximize darwinian fitness in the face of trade-offs and constraints; the numerical results usually depend on the exact form of the trade-offs or constraints. But not always : for example, earlier work predicted that the optimal range in offspring size ought to show a -1 scaling with small litter size, independent of most details of the underlying offspring-survival/offspring-size trade-off relation. Here I report that in non-growing (stationary) age-structured populations, three major life-history attributes (age at first breeding, size of an …
Alterations In Human B Cell Calcium Homeostasis By Polycyclic Aromatic Hydrocarbons: Possible Associations With Cytochrome P450 Metabolism And Increased Tyrosine Phosphorylation, Barbara J. Mounho
Pharmaceutical Sciences ETDs
Polycyclic aromatic hydrocarbons (PAHs), are known immunotoxicants in animals, and are suspect toxins to the human immune system. The mechanism(s), however, by which PAHs exert immunosuppression have not been fully elucidated. Previous studies conducted in our laboratory have shown that PAHs, such as 7,12-dimethylbenz(a)- anthracene (DMB A) and benzo(a)pyrene (BaP) may exert their immunotoxic effects by altering intracellular calcium (Ca2+) homeostasis in lymphocytes. Intracellular Ca2+ is an important second messenger in the immune response, and the mobilization of Ca2+ is critical in the transduction of intracellular signals from the plasma membrane to the nucleus. The overall objective of this project …
Stream Organic Matter Budgets, J.R Webster, Judy L. Meyer
Stream Organic Matter Budgets, J.R Webster, Judy L. Meyer
Long Term Ecological Research Network
This analysis of organic matter dynamics in streams has 3 objectives: 1) to explore the relationships between physical characteristics of streams and their watersheds (climate, geomorphology) and steam organic matter dynamics using data from a broad geographic area; 2) to compare steam organic matter dynamics in a diverse array of steams in order to suggest determinants of observed patterns; and 3) to reveal deficiencies in currently available data on organic matter dynamics in steams. Streams were included in this analysis not to represent the global diversity of stream types but because organic matter data were available. In the introductory chapter …
Specimen Catalog, Tagide Decarvalho
Specimen Catalog, Tagide Decarvalho
Division of Mammals - Field Notes and Catalogs
No abstract provided.
Specimen Catalog, Benjamin J. Frey
Specimen Catalog, Benjamin J. Frey
Division of Mammals - Field Notes and Catalogs
No abstract provided.