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Investigating The Role Of Bromodomain Proteins On Histone Post-Translational Modifications In Toxoplasma Gondii, Joshua Steven Berthiaume
Investigating The Role Of Bromodomain Proteins On Histone Post-Translational Modifications In Toxoplasma Gondii, Joshua Steven Berthiaume
Honors Theses and Capstones
Toxoplasma gondii is a prevalent pathogenic parasite that infects approximately 25 percent of the US population. For the parasite to successfully establish and maintain infection in its host, properly controlled regulation of gene expression is critical. One way Toxoplasma regulates gene expression is through modification of histone proteins that bind to DNA and can control gene accessibility. Acetylation is a modification that is added to histones that changes chromatin structure to enhance gene activation. Histone acetylation can also regulate gene expression by recruitment of important regulators such as bromodomain proteins (BDP). A previous study showed that loss of the bromodomain …
Factor Fiction? Identifying A Putative Toxoplasma Gondii Transcriptional Complex, Julia M. Paquette
Factor Fiction? Identifying A Putative Toxoplasma Gondii Transcriptional Complex, Julia M. Paquette
Honors Theses and Capstones
Toxoplasma gondii is a highly prevalent protozoan parasite that is estimated to infect 30-50% of the global population, though there is no treatment for chronic infection and current treatments for acute infection may have serious side effects. Transcription is a tightly regulated process in T. gondii, allowing the parasite to successfully invade and replicate within host cells, and it is thus a promising avenue to study gene regulation and to investigate possible novel therapeutics. In our lab’s previous research, a TFIID-like complex was identified in T. gondii and found to be associated with the parasite specific bromodomain protein BDP3. …