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Genetic Analysis Of Zebrafish Gli1 And Gli2 Reveals Divergent Requirements For Gli Genes In Vertebrate Development, Rolf O. Karlstrom, Oksana V. Tyurina, Atsushi Kawakami, Noriyuki Nishioka, William S. Talbot, Hiroshi Sasaki, Alexander F. Schier
Genetic Analysis Of Zebrafish Gli1 And Gli2 Reveals Divergent Requirements For Gli Genes In Vertebrate Development, Rolf O. Karlstrom, Oksana V. Tyurina, Atsushi Kawakami, Noriyuki Nishioka, William S. Talbot, Hiroshi Sasaki, Alexander F. Schier
Biology Department Faculty Publication Series
Gli proteins regulate the transcription of Hedgehog (Hh) target genes. Genetic studies in mouse have shown that Gli1 is not essential for embryogenesis, whereas Gli2 acts as an activator of Hh target genes. In contrast, misexpression studies in Xenopus and cultured cells have suggested that Gli1 can act as an activator of Hh-regulated genes, whereas Gli2 might function as a repressor of a subset of Hh targets. To clarify the roles of gli genes during vertebrate development, we have analyzed the requirements for gli1 and gli2 during zebrafish embryogenesis. We report that detour (dtr) mutations encode loss-of-function alleles …