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Genetic Analysis Of Zebrafish Gli1 And Gli2 Reveals Divergent Requirements For Gli Genes In Vertebrate Development, Rolf O. Karlstrom, Oksana V. Tyurina, Atsushi Kawakami, Noriyuki Nishioka, William S. Talbot, Hiroshi Sasaki, Alexander F. Schier Jan 2003

Genetic Analysis Of Zebrafish Gli1 And Gli2 Reveals Divergent Requirements For Gli Genes In Vertebrate Development, Rolf O. Karlstrom, Oksana V. Tyurina, Atsushi Kawakami, Noriyuki Nishioka, William S. Talbot, Hiroshi Sasaki, Alexander F. Schier

Biology Department Faculty Publication Series

Gli proteins regulate the transcription of Hedgehog (Hh) target genes. Genetic studies in mouse have shown that Gli1 is not essential for embryogenesis, whereas Gli2 acts as an activator of Hh target genes. In contrast, misexpression studies in Xenopus and cultured cells have suggested that Gli1 can act as an activator of Hh-regulated genes, whereas Gli2 might function as a repressor of a subset of Hh targets. To clarify the roles of gli genes during vertebrate development, we have analyzed the requirements for gli1 and gli2 during zebrafish embryogenesis. We report that detour (dtr) mutations encode loss-of-function alleles …


Aluminum Rapidly Depolymerizes Cortical Microtubules And Depolarizes The Plasma Membrane: Evidence That These Responses Are Mediated By A Glutamate Receptor, M Sivaguru, S Pike, W Gassmann, Ti Baskin Jan 2003

Aluminum Rapidly Depolymerizes Cortical Microtubules And Depolarizes The Plasma Membrane: Evidence That These Responses Are Mediated By A Glutamate Receptor, M Sivaguru, S Pike, W Gassmann, Ti Baskin

Biology Department Faculty Publication Series

No abstract provided.


Period Gene Expression In Mouse Endocrine Tissues, El Bittman, L Doherty, Ly Huang, A Paroskie Jan 2003

Period Gene Expression In Mouse Endocrine Tissues, El Bittman, L Doherty, Ly Huang, A Paroskie

Biology Department Faculty Publication Series

No abstract provided.


The Effects Of Gape Angle And Bite Point On Bite Force In Bats, Elizabeth R. Dumont, Anthony Herrel Jan 2003

The Effects Of Gape Angle And Bite Point On Bite Force In Bats, Elizabeth R. Dumont, Anthony Herrel

Biology Department Faculty Publication Series

Models of mammalian mastication predict that bite force is affected by both the degree of mouth opening (gape angle) and the point along the tooth row at which force is transferred to a food item (bite point). Despite the widespread use of these models in comparative analyses, experimental data documenting bite force in non-human mammals are extremely limited. The goal of this study is to document variation in non-stimulated bite force associated with change in gape angle and bite point in a broad range of species. We focus on plant-visiting bats because they exhibit a relatively primitive cranial morphology and …