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The Structural And Folding Characteristics Of The Plasmid-Encoded Toxin From Enteroaggregative Escherichia Coli, Patricia Scaglione
The Structural And Folding Characteristics Of The Plasmid-Encoded Toxin From Enteroaggregative Escherichia Coli, Patricia Scaglione
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Plasmid-encoded toxin (Pet) from enteroaggregative Escherichia coli is a member of the autotransporter subfamily termed SPATE (serine protease autotransporters of Enterobacteriaceae). Autotransporters, which are the most common Gram-negative secreted virulence factors, contain three functional domains: an amino terminal leader sequence, a mature protein or passenger domain, and a carboxy-terminal β domain. The leader sequence targets the protein to the periplasmic space and the β domain then forms a β-barrel pore in the outer membrane of the bacterium which allows the passenger domain to enter the external milieu. In some cases the passenger domain is cleaved from the β-barrel at the …