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Antimalarial; Antiplasmodial; Dd2; Drug discovery; Drug screening; Falciparum; Malaria; Marine extracts; Microbial extracts; Mts; Plasmodium; Selectivity index; Sybr green i.
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Identification Of Potential Lead Antimalarial Compounds From Marine Microbial Extracts, Abigail Carbonell
Identification Of Potential Lead Antimalarial Compounds From Marine Microbial Extracts, Abigail Carbonell
HIM 1990-2015
Malaria, caused by the parasite Plasmodium falciparum, has a long history as a global health threat. The vector-borne disease causes millions of deaths yearly, especially in developing countries with tropical climates that facilitate transmission. Compounding the problem is the emergence of drug-resistant strains due to overuse of outdated treatments. New compounds with antiplasmodial activity are needed to be developed as effective drugs against malaria. The hypothesis for this project is that marine microorganisms have a high likelihood of yielding novel antiplasmodial chemotypes because of their high diversity, which has not yet been explored for antimalarial development. In this project, microbes …