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Alpha v beta 3 integrin; Angiogenesis; Cell bio imaging; Cyclic rgd; Early tumor detection; Fluorescence; Long lifetimes; Luminescent; Organometalic probes; Rgd peptide; Rgd ruthenium bipyridine complex; Ruthenium; Ruthenium bipyridine
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Development Of Luminescent Ruthenium Complexes For In-Vitro Fluorescence Imaging Of Angiogenesis With The Rgd Peptide, Rosemary Victoria
Development Of Luminescent Ruthenium Complexes For In-Vitro Fluorescence Imaging Of Angiogenesis With The Rgd Peptide, Rosemary Victoria
HIM 1990-2015
Herein we report the synthesis of an RGD-ruthenium bipyridine [Ru(Bpy)2(BpyRGD)]2+ complex aimed at the detection of angiogenesis. Angiogenesis plays a critical role in many pathophysiological processes, such as tumor growth. The αv-integrins (αv[beta]3, αv[beta]5) are currently used as molecular targeting sites for anti-angiogenic therapies. The [Ru(Bpy)2(BpyRGD)]2+ complex is an organometallic luminescent probe, which enables noninvasive, in vitro imaging of αv[beta]3 expression. Peptides containing the arginine-glycine-aspartic acid (RGD) sequence have been shown to bind strongly to the αvb3 integrin. The RuBpy probes are soluble in water, display long lifetimes, and are photochemically stable. These properties enable the Ru(tris-bpy) complexes to be …