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- Keyword
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- Apoa1; Hepatic lipase; Hepatocytes; Lipoprotein; Trafficking (1)
- Bifc; Fluorescent tools; Large stokes shift; M pfc; Mcherry; Mycobacterium tuberculosis; Tb (1)
- Binary; Deoxyribozyme; Detection; Dnazyme; Drug; Drugr; Mtb; Mycobacterium; Nucleotide; Polymorphism; Resistance; Single; Snp; Tb; Tuberculosis (1)
- Biosensors (1)
- Cardiac rehabilitation; Cardiovascular disease; Exercise science; Functional capacity; Heart attack; Myocardial infarction; Secondary prevention (1)
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- Charcot marie tooth; Cmt; Cmt20; Dync1h1; Dynein (1)
- Deoxyribozyme (1)
- Diffusion limitation (1)
- Dna nanotechnology (1)
- Dz 10-23 (1)
- Falciparum; Pfmrk; Pfpk5; Pfpk6; Plasmodium (1)
- Limit of detection (1)
- Mycobacterium tuberculosis (1)
- Orp 10 (1)
- Very low density lipoprotein (1)
- Very low density lipoprotein transport vesicle (1)
- Vldl (1)
- Vtv (1)
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Effectiveness Of Cardiac Rehabilitation: Secondary Prevention Increases Functional Capacity In Myocardial Infarction Patients, Kristin Badillo
Effectiveness Of Cardiac Rehabilitation: Secondary Prevention Increases Functional Capacity In Myocardial Infarction Patients, Kristin Badillo
HIM 1990-2015
The purpose of this study was to discern the effectiveness of Cardiac Rehabilitation/ Secondary Prevention Programs (CR/ SPP’s) by evaluating increased functional capacity in the form of MET (metabolic equivalent) scores post-myocardial infarction (MI) or heart attack. The Duke Activity Status Index (DASI) survey is administered as part of the Standard Operating Procedure (SOP) for participation in the Secondary Prevention Program. Criterion for the research included patients 65 and older, with a history of one myocardial infarction, and had completed all 36 sessions of CR. The scores from 11 SPP surveys were analyzed and compared in three time increments from …
Characterizing The Onset And Progression Of Charcot-Marie-Tooth Neuropathy In H304r Mutant Mice, Aaron Ledray
Characterizing The Onset And Progression Of Charcot-Marie-Tooth Neuropathy In H304r Mutant Mice, Aaron Ledray
HIM 1990-2015
Dynein is a motor protein complex that transports various types of intracellular cargos from the cell periphery towards the cell center. Dynein mutations are linked to several neurodegenerative diseases, including Charcot-Marie-Tooth disease (CMT). A mouse model of CMT was generated with a knock-in H304R dynein allele. This mutation at position 304 corresponds to the H306R mutation found in humans that can cause CMT. Here, a behavioral test was developed to study the onset and progression of CMT symptoms in these mice. In the tail suspension test, mice were suspended briefly by their tails and the posture of their hind limbs …
Hepatic Lipase Regulates Lipoprotein Trafficking In Hepatocytes, Simeon Thibeaux
Hepatic Lipase Regulates Lipoprotein Trafficking In Hepatocytes, Simeon Thibeaux
HIM 1990-2015
The production of very low density lipoprotein and high density lipoprotein particles by the liver is a tightly regulated process, which begins with synthesis and assembly of core protein components in the rough endoplasmic reticulum. Factors influencing the production and metabolism of these particles are of immediate medical relevance, as their malfunction or hyperactivity can lead to an assortment of disease states. Hepatic lipase is a secreted liver enzyme, with many previously described roles in the metabolism and clearance of both high and low density lipoproteins. Increased production and assembly of this enzyme is an indicator of metabolic dysfunction, while …
Using Antenna Tile-Assisted Substrate Delivery To Improve Detection Limits Of Deoxyribozyme, Amanda J. Cox
Using Antenna Tile-Assisted Substrate Delivery To Improve Detection Limits Of Deoxyribozyme, Amanda J. Cox
HIM 1990-2015
One common limitation of enzymatic reactions is the diffusion of a substrate to the enzyme active site and/or the release of the reaction products. These reactions are known as diffusion –controlled. Overcoming this limitation may enable faster catalytic rates, which in the case of catalytic biosensors can potentially lower limits of detection of specific analyte. Here we created an artificial system to enable deoxyribozyme (Dz) 10-23 based biosensor to overcome its diffusion limit. The sensor consists of the two probe strands, which bind to the analyzed nucleic acid by Watson-Crick base pairs and, upon binding re-form the catalytic core of …
Regulation Of Vldl Trafficking By Orp 10, Philip A. Wessels
Regulation Of Vldl Trafficking By Orp 10, Philip A. Wessels
HIM 1990-2015
Of the challenges facing the improvement of human health, none has taken the forefront quite like the endeavor to discover novel treatments for heart disease. As heart disease has now become the leading cause of death throughout the world [1], the medical community has made incredible strides in the mission to treat atherosclerosis which is the major contributor to heart disease. Very Low Density Lipoproteins (VLDL) are secreted by the liver and subsequently converted to Low Density Lipoproteins (LDL). Many factors contribute to the narrowing of the arterial walls, however oxidized LDL is the main factor that leads to the …
Detection Of Drug-Resistance Conferring Snps In Mycobacterium Tuberculosis Using Binary Dnazymes, Marina Addario
Detection Of Drug-Resistance Conferring Snps In Mycobacterium Tuberculosis Using Binary Dnazymes, Marina Addario
HIM 1990-2015
Mycobacterium tuberculosis (Mtb) is the pathogen that causes Tuberculosis (TB) and is responsible for an average of 1.5 million deaths annually. Although a treatment regimen does exist, Multi-Drug Resistant (MDR-TB) and eXtremely Drug Resistant (XDR-TB) TB strains are becoming a more prevalent concern partly due to failure of patient compliance with the current six to nine month drug treatment regimen. The current diagnostic methods are not able to identify these MDR and XDR-TB strains efficiently therefore more effective point-of-care (POC) diagnostics and drug susceptibility testing (DST) are urgently needed to detect drug resistance and facilitate prompt, appropriate treatment plans. In …
Development Of Novel Fluorescent Tools For Investigating Virulence Factors And Drug Susceptibility In Mycobacterium Tuberculosis, Kaley Wilburn
Development Of Novel Fluorescent Tools For Investigating Virulence Factors And Drug Susceptibility In Mycobacterium Tuberculosis, Kaley Wilburn
HIM 1990-2015
Mycobacterium tuberculosis (Mtb) is the causative agent of Tuberculosis (TB), a life-threatening disease primarily affecting the lungs that infects about one third of the world's population and causes 1.3 million deaths annually. It is estimated that TB has been infecting humans for around 70,000 years and has killed more people than any other infectious disease. The highly effective, persistent, and multifaceted virulence strategies that have allowed Mtb to continue to spread and thrive for so long are still poorly understood at the molecular level. This lack of knowledge contributes to ongoing challenges to curing TB. Although drugs capable of killing …
Elucidating The Molecular Pathway Of Atypical Plasmodium Falciparum Kinases Through Substrate Characterization, Daniel Segarra
Elucidating The Molecular Pathway Of Atypical Plasmodium Falciparum Kinases Through Substrate Characterization, Daniel Segarra
HIM 1990-2015
Plasmodium falciparum, the organism responsible for the most prevalent and most virulent cases of malaria in humans, poses a major burden to the developing world. The parasite is increasingly developing resistance to traditional therapies, such as chloroquine, so the need to determine novel drug targets is more prevalent than ever. One such method involves targeting proteins unique to the malarial proteome that do not have homologues in humans. An especially promising group of targets are protein kinases, which are involved in many different biochemical pathways within the cell. Eukaryotic cell cycle progression is moderated by a family of protein kinases …