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- Aerobic exercises; Low back pain (1)
- Aerobic; Ambulatory; Cardiography; Exercise; Impedance (1)
- Aids; Asia; Hiv intervention; Sew workers; The 100% condom use program; The sonagachi project (1)
- Alpha v beta 3 integrin; Angiogenesis; Cell bio imaging; Cyclic rgd; Early tumor detection; Fluorescence; Long lifetimes; Luminescent; Organometalic probes; Rgd peptide; Rgd ruthenium bipyridine complex; Ruthenium; Ruthenium bipyridine (1)
- Amino lipids; Enterococci; Mutant strains (1)
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- Amplex red; Cyclic voltammetry; Dopaminergic; H2o2; Hydrogen peroxide; Parkinson's; Reactive oxygen species; Ros (1)
- Antimalarial drug discovery natural product like (1)
- Atherosclerosis; Hsc 70; Snare; Vldl (1)
- Bacterial vaginosis; Female reproductive tract; Hiv; Innate immunity; Microbicide; Mucosal immunology; Rc 101 (1)
- Falciparum; Kinase; Malaria; Pfpk5; Pfpka; Phosphoproteomics; Phosphorylation; Pk5; Pka; Plasmodium; Protein (1)
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The Role Of Hsc-70 In Very Low Density Lipoprotein Tranport Vesicle Golgi Fusion Complex Formation, Erika Nafi Valencia
The Role Of Hsc-70 In Very Low Density Lipoprotein Tranport Vesicle Golgi Fusion Complex Formation, Erika Nafi Valencia
HIM 1990-2015
Excess production and secretion of very low-density lipoprotein (VLDL) by the liver into the circulatory system is directly related to atherosclerosis, a chronic cardiovascular disease that threatens the lives of many worldwide and continues to be a leading cause of death in the United States. The rate-limiting step in VLDL secretion is its transport from the site of biogenesis, the hepatic endoplasmic reticulum to the cis-Golgi. This step is mediated by a specialized ER- derived vesicle, the VLDL transport vesicle (VTV). Upon exit of the ER the VTV targets, fuses and delivers VLDL into the lumen of the Golgi. The …
Amyloid-Beta42 Toxicity Reduction In Human Neuroblastoma Cells Using Cholera Toxin B Subunit-Myelin Basic Protein Expressed In Chloroplasts, Alexandra Ayache
Amyloid-Beta42 Toxicity Reduction In Human Neuroblastoma Cells Using Cholera Toxin B Subunit-Myelin Basic Protein Expressed In Chloroplasts, Alexandra Ayache
HIM 1990-2015
Alzheimer's disease (AD) is an age progressive neurodegenerative brain disorder, affecting 37 million people worldwide. Cleavage of amyloid precursor protein by ?- and ?-secretase produces the amyloid-beta (A?) protein, which significantly contributes to AD pathogenesis. The A? aggregates, formed at the surface of neurons and intracellularly, cause neurotoxicity and decrease synaptic function. Inhibiting or degrading A? accumulation is a key goal for development of new AD treatments. Evidence shows that human Myelin Basic Protein (MBP) binds to and degrades A? thereby, preventing cytotoxicity. A potential method for oral drug delivery that will allow plant-derived bioencapsulated MBP to pass through intestinal …
Multiple Aspects Of Natural Killer Cell Expansion In Relevance To Immunotherapy For Hematologic Malignancies, Dominic Colosimo
Multiple Aspects Of Natural Killer Cell Expansion In Relevance To Immunotherapy For Hematologic Malignancies, Dominic Colosimo
HIM 1990-2015
Natural Killer (NK) cells are a subset of lymphocytes that regulate adaptive immune responses and utilize "missing self" recognition to activate anti-tumor and anti-viral cytotoxicity. Clinical research, as well as murine and ex vivo models, have shown that a variety of NK cell applications have proven useful as immunotherapeutic treatments for patients with hematologic malignancies. However, the selective expansion of NK cells to yield relevant amounts of these lymphocytes has been a major hurdle in the development of methods for clinical therapeutic use. Here, we demonstrate a novel ex vivo expansion method utilizing k562 leukemic cell lines and soluble cytokines …
Determination Of Selectivity And Potential For Drug Resistance Of Novel Antimalarial Compounds From Nature-Inspired Synthetic Libraries, Eric Keasler
HIM 1990-2015
As malaria, caused by Plasmodium spp., continues to afflict millions of people worldwide, there is a dire need for the discovery of novel, inexpensive antimalarial drugs. Although there are effective drugs on the market, the consistent development of drug resistant species has decreased their efficacy, further emphasizing that novel therapeutic measures are urgently needed. Natural products provide the most diverse reservoir for the discovery of unique chemical scaffolds with the potential to effectively combat malarial infections, but, due to their complex structures, they often pose extreme challenges to medicinal chemists during pharmacokinetic optimization. In our laboratory we have performed unbiased, …
Identification Of Plasmodium Falciparum Protein Kinase Substrates And Interacting Proteins, Jessica Yap
Identification Of Plasmodium Falciparum Protein Kinase Substrates And Interacting Proteins, Jessica Yap
HIM 1990-2015
Characterization of PfPKA and PfPK5 substrates, as well as the proteins they interact with, will help us to develop innovative therapies targeting binding sites.; Malaria is a devastating disease that results in almost one million deaths annually. Most of the victims are children under the age of five in Sub-Saharan Africa. Malaria parasite strains throughout developing countries are continually building resistance to available drugs. Current therapies such as mefloquine, chloroquine, as well as artemisinin are becoming less effective, and this underscores the urgency for therapeutics directed against novel drug targets. In order to identify new drug targets, the molecular biology …
Gold (Iii) Macrocycles Are Dna Intercalators That Inhibit Topoisomerase I And Ii, Alexander Fagenson
Gold (Iii) Macrocycles Are Dna Intercalators That Inhibit Topoisomerase I And Ii, Alexander Fagenson
HIM 1990-2015
Human Topoisomerase IB (TOP1) and Topoisomerase II? (TOP2?) are essential nuclear enzymes that control DNA topology during DNA replication, gene transcription and cell division. These enzymes carry out their catalytic function by making transient single-strand (type I) or double-strand (type II) breaks in the DNA. In vivo, these complexes are short-lived but can be exploited by anti-cancer drugs to mechanistically kill cancer cells. Two general classes of compounds can kill cancer cells through a topo-targeted mechanism. Interfacial Poisons (IFPs) act at the enzyme-DNA interface to inhibit the religation reaction, resulting in the accumulation of DNA double-stand breaks (DSBs) in the …
An Evaluation Of Hiv/Aids Incidence Reduction And Awareness-Raising Interventions Inspired By The Sonagachi Project And The 100% Condom Use Program, Nicole Fernandez
An Evaluation Of Hiv/Aids Incidence Reduction And Awareness-Raising Interventions Inspired By The Sonagachi Project And The 100% Condom Use Program, Nicole Fernandez
HIM 1990-2015
In the past thirty years, HIV/AIDS (Human Immunodeficiency Virus/Acquired Immune Deficiency Syndrome) transformed from a mysteriously lethal disease affecting limited portions of the population to a true global pandemic. Although HIV/AIDS is responsible for the deaths of approximately 30 million people worldwide, prevalence rates are now increasing significantly due to increasing survival rates. However, overall increasing incidence rates now serve as a primary concern for researchers. Avert (2011) suggests that there is a lack of behavioral interventions and prevention programs aimed at decreasing the number of newly affected individuals. This is problematic as it may create not only physical and …
Test-Retest Reliability Of Noninvasive Ambulatory Impedance Cardiography During Aerobic Exercise, Benjamin Germain
Test-Retest Reliability Of Noninvasive Ambulatory Impedance Cardiography During Aerobic Exercise, Benjamin Germain
HIM 1990-2015
Impedance cardiography is an important tool in determining a person's hemodynamic properties. The makers obtained through thoracic impedance have been shown to be of great importance when monitoring critical care patients. Technological developments have made this process noninvasive and ambulatory, opening up new possibilities for potential use. A study was conducted by remotely monitoring healthy subjects (n=5), who performed an 8-minute mild-to-moderate aerobic exercise protocol, followed up by a four minute cognitive stress test. Testing was conducted onsite at Kennedy Space Center in association with the National Aeronautics and Space Administration using the MW1000A (MindWare Technologies LTD, Gahanna, OH) ambulatory …
Design, Construction, And Characterization Of The Ysgr Minimal Codon Fab Library For Chaperone-Assisted Rna Crystallography, Sean Holmes
HIM 1990-2015
Of the entire human genome, 90% of all genetic information is transcribed but only a fraction of that subsequent RNA is translated into proteins. RNAs which are not translated into proteins are deemed non-coding RNAs. Little is known about this large category of noncoding RNAs, although they perform a variety of functions within the cell. RNA crystallography is used to study RNA tertiary structure, which gives insight to the function of these non-coding RNAs. However, complications associated with RNA crystallography arise due to RNA's lack of surface functional group diversity, flexible tertiary structure, and conformational heterogeneity. A novel technique, Chaperone-assisted …
Determination Of The Hydrogen Peroxide Concentration In Rotenone Induced Dopaminergic Cells Using Cyclic Voltammetry And Amplex Red, Kishan Patel
HIM 1990-2015
Parkinson's disease (PD) is a neurodegenerative condition that affects millions of people worldwide. The exact etiology of PD is unknown. However, it is well established that environmental factors contribute to the onset of PD. In particular, chemicals such as the insecticide Rotenone have been shown to increase the death of dopaminergic (DA) neurons by increasing levels of reactive oxygen species (ROS). ROS such as hydrogen peroxide (H2O2) have been shown to be elevated above basal levels in PD patients. Currently, to measure H2O2 concentrations, a commercially available (Amplex® Red) fluorescent assay is used. However, the assay has limitations: it is …
Aerobic Exercise As A Means Of Reducing Low Back Pain A Systematic Review, Theresa Privett
Aerobic Exercise As A Means Of Reducing Low Back Pain A Systematic Review, Theresa Privett
HIM 1990-2015
Background: Low back pain (LBP) is considered the leading cause of inactivity and lost employment time. It can be extremely difficult to treat as most conventional therapies have poor success rates. People with LBP need to be made more aware of the diverse and economical treatments available in order to save on expenses and diminish stress. Patients and healthcare professionals have many choices when deciding on the best plan of care; however, it is often difficult to determine which option is best. Objectives: The purpose of this systematic review was to determine if aerobic exercises play a role in reducing …
Development Of Luminescent Ruthenium Complexes For In-Vitro Fluorescence Imaging Of Angiogenesis With The Rgd Peptide, Rosemary Victoria
Development Of Luminescent Ruthenium Complexes For In-Vitro Fluorescence Imaging Of Angiogenesis With The Rgd Peptide, Rosemary Victoria
HIM 1990-2015
Herein we report the synthesis of an RGD-ruthenium bipyridine [Ru(Bpy)2(BpyRGD)]2+ complex aimed at the detection of angiogenesis. Angiogenesis plays a critical role in many pathophysiological processes, such as tumor growth. The αv-integrins (αv[beta]3, αv[beta]5) are currently used as molecular targeting sites for anti-angiogenic therapies. The [Ru(Bpy)2(BpyRGD)]2+ complex is an organometallic luminescent probe, which enables noninvasive, in vitro imaging of αv[beta]3 expression. Peptides containing the arginine-glycine-aspartic acid (RGD) sequence have been shown to bind strongly to the αvb3 integrin. The RuBpy probes are soluble in water, display long lifetimes, and are photochemically stable. These properties enable the Ru(tris-bpy) complexes to be …
Protection Of The Female Reproductive Tract In The Prevention Of Hiv, Camila Diaz
Protection Of The Female Reproductive Tract In The Prevention Of Hiv, Camila Diaz
HIM 1990-2015
Worldwide, more than half of all HIV-infected individuals are women. Since mucosal surfaces are the primary gateway for HIV entry, maintaining the integrity of the female reproductive tract (FRT) is essential for preventing infection. The FRT employs many immune mechanisms that serve as the first line of defense against HIV transmission. Among these are vaginal fluid secretions rich in antimicrobial peptides, and commensal bacteria that colonize the vagina and prevent infections. We sought to study vaginal fluid as an innate immune component of the FRT in the prevention of HIV infection. Additionally, we investigated the anti-HIV microbicide candidate RC-101 as …
Physiological Relevance Of A Trna-Dependent Mechanism For Membrane Modification In Enterococcus Faecium, Jesse Harrison
Physiological Relevance Of A Trna-Dependent Mechanism For Membrane Modification In Enterococcus Faecium, Jesse Harrison
HIM 1990-2015
Enterococci were once thought to be harmless, commensal organisms that colonize the gastrointestinal tract of humans and other mammals. In the last 30 years, however, concern has grown in the clinical setting over two particular species, Enterococcus faecalis and Enterococcus faecium, which are frequently found to be the etiologic agents of nosocomial infections. Aminoacyl-phosphatidylglycerol synthases (aaPGSs) are integral membrane proteins that add amino acids to phosphatidylglycerol (PG) in the cellular envelope of bacteria. Addition of amino acids to PG confers resistance to various therapeutic antimicrobial agents, and contributes to evasion of the host immune response in a number of clinically …