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Harnessing Electrocorticographic Signals For Neuroscience And Neurosurgery, Adriana De Pesters
Harnessing Electrocorticographic Signals For Neuroscience And Neurosurgery, Adriana De Pesters
Legacy Theses & Dissertations (2009 - 2024)
Daily human activities, such as speaking, driving or listening to music, are produced by activations of neurons in the brain. Where, when and how these activations occur has been the subject of intense debate for the last decades. Traditional techniques to image the human brain, such as functional magnetic resonance imaging (fMRI) or electroencephalography (EEG), only provide limited information regarding where and when these activations take place. For that reason, critical information is currently missing regarding how neurons from different parts of the brain interact and coordinate their activity to implement behavior. This information is critical to understand human behavior …
Analysis Of Candidate Genes For Seizure Susceptibility In Epileptogenesis, Brittany O'Brien
Analysis Of Candidate Genes For Seizure Susceptibility In Epileptogenesis, Brittany O'Brien
Legacy Theses & Dissertations (2009 - 2024)
The occurrence of recurrent spontaneous seizures is the hallmark of epilepsy. The key to understanding how a normal brain can develop epilepsy through a process known as epileptogenesis is identifying susceptibility factors. Previously, various strains of inbred mice from the hybrid mouse diversity panel were subjected to multiple seizures via the repeated flurothyl model (RFM) for epileptogenesis. The results demonstrated differences in kindling among the inbred strains; specifically two main trends in the generalized seizure threshold (GST) data were kindling-sensitive and kindling-resistant strains. In addition, genome wide association studies done from these mice demonstrated a quantitative trait locus (QTL) on …