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Chronic Arsenic Exposure In Nanomolar Concentrations Accelerates Senescent Phenotypes In Vitro, Heather M. Sabo
Chronic Arsenic Exposure In Nanomolar Concentrations Accelerates Senescent Phenotypes In Vitro, Heather M. Sabo
Biological Sciences
Arsenic is recognized as an environmental carcinogen, in which over 100 million individuals worldwide experience chronic exposure through contaminated drinking water. Arsenic exposure is linked to several health conditions, such as cancer, diabetes, skin lesions, immune dysfunction, and cardiovascular disease. Here we test the hypothesis that toxicants, such as arsenic, accelerate the program of senescence. Human (IMR-90) primary diploid fibroblasts were chronically exposed to arsenic at nanomolar concentrations and the impact on the expression of senescent-associated mRNAs was evaluated. IMR-90 cells were exposed either to untreated media or exposed to 130nM and 330nM AsCl3 supplemented media. RNA samples were extracted …
Bhlhe40-As1 A Long-Noncoding Rna Regulates Dec1 On Breast Cancer Progression, Denisse Duran-Reyes
Bhlhe40-As1 A Long-Noncoding Rna Regulates Dec1 On Breast Cancer Progression, Denisse Duran-Reyes
Biological Sciences
Ductal Carcinoma in Situ (DCIS) is a precursor to breast cancer where abnormal cells have been found in the mammary duct but have not become invasive and spread into surrounding tissue. There has been an increase in early diagnosis of DCIS, but only around 40% of the cases ever progress to an invasive stage, and thus detection can lead to unnecessary surgeries. To identify which of these 40% progress, long noncoding RNAs were used. Through RNA sequencing of DCIS and invasive cells from real patient samples, BHLHE40 - AS1 was discovered, a long - noncoding R NA, to be highly …
Exploration Of The Interactions Between Amyloid-Beta Protein And Insulin In Various Ionic Conditions, Quade Goldenberg
Exploration Of The Interactions Between Amyloid-Beta Protein And Insulin In Various Ionic Conditions, Quade Goldenberg
Biological Sciences
Alzheimer’s disease (AD) is characterized by tau tangles and amyloid - β (Aβ) peptide aggregates amyloids in the brain, specifically in the hippocampus. Aβ plaques are known to form primarily in the extracellular space aroun d neuronal cells, interfering with synaptic transmission. The aggregation of Aβ in the hippocampus is associated with a decline in hippocampally - mediated cognitive abilities, which is a symptom of AD. AD has a strong correlation to type 2 diabetes mellitus (T2DM), which is defined by hyperinsulinemia and dysregulated glucose metabolism. It has been shown that insulin plays a role in both memory and learning …
Transcriptional Regulation Of Dksa P3 Promoter In Escherichia Coli, Chibuokem Ikwuazom
Transcriptional Regulation Of Dksa P3 Promoter In Escherichia Coli, Chibuokem Ikwuazom
Biological Sciences
DksA, a global gene regulator, binds to RNA po lymerase to regulate transcription initiation in Escherichia coli . It negatively regulates transcription of some genes, such as those for ribosomal RNAs and fis , and positively regulates transcription of other genes, including genes involved in amino acid biosynthesis. Little is known about how DksA itself is regulated. Current work in our lab has shown three major promoters, a σ 70 dependent P 1 promoter and two σ 38 (RpoS) - dependent promoters (P 2 and P 3 ), regulate the transcription of dksA . More is current ly known about …
Mulitmodal Molecular Mechanisms Control Germline Stem Cell Differentiation In Drosophila, Mohamad Nasrallah
Mulitmodal Molecular Mechanisms Control Germline Stem Cell Differentiation In Drosophila, Mohamad Nasrallah
Biological Sciences
Stem cells have the intrinsic ability to divide to form a stem cell daughter, while also retaining the ability to self - renew. These qualities are critical , as improper stem cell maintenance is implicit in aging and provokes diseases such as cancer. We previously revealed that during Drosophila oogenesis, transcriptional silencing mediated by polar granule component (pgc) alters the germ line cell cycle to promote germ line stem cell (GSC) differentiation. O ur work with pgc suggested that cell cycle regulation might be an important general mecha nism to facilitate division GSCs into daughter stem cells (or cystoblast, CBs), …
Controllable And Sequential Activation Of Cancer Nanotherapy For Enhanced Synergistic Effec, Vincent E. Lamantia
Controllable And Sequential Activation Of Cancer Nanotherapy For Enhanced Synergistic Effec, Vincent E. Lamantia
Biological Sciences
The treatment of numerous disease states has become increasingly more complex and challenging, even as we come out with new pharmacological and technological advancements. It is well known that cancer is not one disease, but many diseases that progress and present new challenges with each patient. With this we present a novel design which uses biorthogonal chemistry and magnetic nanoparticles (MNP’s) to create a drug delivery system with the capability to deliver two drugs that are released at two different time points under the direction of a single trigger. This innovative combination of multiple advancements will allow for the treatment …