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Apoptotic Effect Of Bortezomib On Pancreatic Islet Cells In Stz-Induced Diabetic Rats, Çiğdem Ekin, Neslihan Tekin Karacaer, Mehtap Tarhan Karaoğlan, Ibrahim Örün, Kamile Öztürk
Apoptotic Effect Of Bortezomib On Pancreatic Islet Cells In Stz-Induced Diabetic Rats, Çiğdem Ekin, Neslihan Tekin Karacaer, Mehtap Tarhan Karaoğlan, Ibrahim Örün, Kamile Öztürk
Makara Journal of Health Research
Background: This study aimed to investigate the possible apoptotic role of bortezomib (BMZ) on pancreatic islets of streptozotocin (STZ)-induced diabetic rats.
Methods: Sprague-Dawley rats were divided into groups that were administered BMZ alone or in combination with STZ. To evaluate the effect of BMZ on the development of diabetes, blood glucose levels were measured regularly in the animals. Islet cell viability was determined by staining the islets with fluorescein diacetate and propidium iodide. Expression of the Bcl-2 and bax genes was determined in islet cells by quantitative real-time polymerase chain reaction.
Results: Administering STZ-induced hyperglycemia in the …
Body Image Perception And Its Association With Food Intake Among Undergraduate Students In Kuala Lumpur, Malaysia, Christie Loke Sin Mun, Roslee Rajikan, Hanis Mastura Yahya
Body Image Perception And Its Association With Food Intake Among Undergraduate Students In Kuala Lumpur, Malaysia, Christie Loke Sin Mun, Roslee Rajikan, Hanis Mastura Yahya
Makara Journal of Health Research
Background: Body image dissatisfaction may lead to the practice of imbalanced diet to achieve the desired body weight. This study aimed to determine the association between body image perception and food intake among undergraduate students.
Methods: This cross-sectional study was conducted on the data of 155 students from three faculties located at National University of Malaysia, Kuala Lumpur. Assessments included demographic data, body mass index, Contour Drawing Rating Scale, and 3-day food records.
Results: The majority of the subjects were categorized as normal weight (64.5%), and the remaining were classified as underweight (26.5%), overweight (7.7%), and obese …
Evaluation Of Biochemical And Pathological Parameters At Different Doses Of Cisplatin In Experimental Animal Model: Toxicological Study On An Antineoplastic Drug, Farhana Sultana, Muhammed Mohibul Islam, Mohammad Nurul Amin, Nusrat Jahan, Asma Kabir, Talha Bin Emran, Bibek Chandra Sutradhar, Sujan Banik
Evaluation Of Biochemical And Pathological Parameters At Different Doses Of Cisplatin In Experimental Animal Model: Toxicological Study On An Antineoplastic Drug, Farhana Sultana, Muhammed Mohibul Islam, Mohammad Nurul Amin, Nusrat Jahan, Asma Kabir, Talha Bin Emran, Bibek Chandra Sutradhar, Sujan Banik
Makara Journal of Health Research
Background: This study aimed to assess the effect of cisplatin-induced toxicities on biochemical and pathological parameters such as body, liver, and kidney weights, blood urea nitrogen (BUN), creatinine, alanine aminotransferase (ALT), and blood cells (RBCs and WBCs) in white Swiss albino mice.
Methods: Cisplatin’s potential toxic effects on body, liver, and kidney weights were evaluated using standard laboratory methods. Blood biochemical levels such as BUN, creatinine, and ALT levels were determined by an auto-hemolyzer using commercial diagnostic kits. Blood cells (RBCs and WBCs) were counted under a microscope by a hemocytometer.
Results: Cisplatin’s potential toxic effects on …