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The Linkage Between Hpa Axis Dysregulation And Metabolic Syndrome, Brianna Godlewski
The Linkage Between Hpa Axis Dysregulation And Metabolic Syndrome, Brianna Godlewski
Honors Theses
A diagnosis of Metabolic Syndrome (MSX) requires patients to present with three or more of the following symptoms: elevated fasting blood glucose levels, elevated serum triglyceride levels, low serum HDL levels, elevated blood pressure, and truncal obesity. This pathology shares many similarities with Cushing’s Syndrome (CS) but a diagnosis of CS requires hypercortisolemia. This similarity has led our lab and others to hypothesize that MSX may be a Cushingoid-like state caused by hypersensitivity of the glucocorticoid receptor (GR), a nuclear hormone receptor that is activated when cortisol binds, and or hyperactivity of the enzyme 11beta-hydroxysteroid dehydrogenase (11?- HSD) type 1, …
Development Of Novel Allele Specific Pcr Based Assays To Investigate The Contribution Of Cortisol To Metabolic Syndrome And It's Potential Implications In Depression Treatment, Justin Robert Salm
Development Of Novel Allele Specific Pcr Based Assays To Investigate The Contribution Of Cortisol To Metabolic Syndrome And It's Potential Implications In Depression Treatment, Justin Robert Salm
Honors Theses
The shared circuitries of depression and the stress response, regulated by the Hypothalamic-Pituitary-Adrenal (HPA) axis, implies that major depression may reflect dysregulations of the HPA axis. Previous studies find that that melancholic depression is accompanied by hyperactive HPA activity, anxiety, insomnia etc. Adversely, patients with atypical depression present CRH deficiency accompanied by lethargy and fatigue. According to the corticosteroid receptor hypothesis, HPA axis dysregulation that causes these variable phenotypic depressive moods may be attributed to defective GR expression or function. Multiple GR polymorphisms that could impact its expression or function have been identified. Due to limitations, it was not feasible …
Lack Of Glucocorticoid Receptor Hypersensitivity-Related Polymorphisms In An Undergraduate Population, Evan Leibovitz
Lack Of Glucocorticoid Receptor Hypersensitivity-Related Polymorphisms In An Undergraduate Population, Evan Leibovitz
Honors Theses
Obesity is a currently a major problem plaguing the world as a whole. The International Obese Task Force (IOTF) estimates at least 1.1 billion adults are overweight with some 312 million of those obese, globally. 1 As of 2004, in less than twenty years, the prevalence of obesity had more than doubled in adults with childhood obesity prevalence rising even more rapidly. Obesity, however, can be classified as a disease of its own or as a symptom of another disease. Two such diseases that have obesity as a symptom are Metabolic Syndrome and Cushing ’s syndrome. Metabolic Syndrome is a …