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The Ttc7Fsn/Fsn Mutation Results In Hyperactivation Of Lymphocytes And Overproduction Of Il-4 Leading To The Development Of Systemic Autoimmunity, Beth Lindroth Hill

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Ttc7^fsn/fsn mice exhibit systemic autoimmunity characterized by hyperactivated B cells, increased interleukin-4, autoantibodies, kidney disease and reduced lifespan. Because the pathology is similar to systemic lupus erythematosus, Ttc7^fsn/fsn mice are a useful model with which to study early events that lead to autoimmune disease. Although the Ttc7^fsn mutation has been identified the gene function is unknown. The phenotype of Ttc7^fsn/fsn mice mimics the Th2 autoimmunity of the IL-4 transgenic (Erb et al 1997). It was previously unknown whether the over-production of IL-4 was an intrinsic defect of Ttc7^fsn/fsn lymphocytes that led to autoimmunity, or, whether …