Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
The Role Of Autophagy In The Sensitivity Of Osteosarcoma Cells To Gemcitabine Treatment, Janice M. Santiago-O'Farrill
The Role Of Autophagy In The Sensitivity Of Osteosarcoma Cells To Gemcitabine Treatment, Janice M. Santiago-O'Farrill
Dissertations & Theses (Open Access)
Despite treatment improvement for osteosarcoma (OS), overall survival has remained unchanged in the last 20 years. Pulmonary metastasis continues to be the main cause of death; novel therapeutic strategies are urgently needed to improve the survival rate of these patients. Previous data in our laboratory has demonstrated that aerosol gemcitabine (GCB) treatment has a significant therapeutic effect on metastatic OS. However, treatment efficacy is decreased due to acquired resistance by a population of tumor cells that fails to respond to treatment. Recent studies have implicated autophagy as a resistance mechanism in various types of cancer. The purpose of this study …