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Altered Responses To Endoplasmic Reticulum Stress In Pancreatic Cancer, Jennifer H. Choe
Altered Responses To Endoplasmic Reticulum Stress In Pancreatic Cancer, Jennifer H. Choe
Dissertations & Theses (Open Access)
Pancreatic ductal adenocarcinoma (PDAC) represents the fourth most common cause of cancer-associated death in the United States. Little progress has been made in understanding how proteotoxic stress affects rapidly proliferating pancreatic tumor cells. Endoplasmic reticulum (ER) stress occurs when protein homeostasis in the ER lumen is perturbed. ER stress activates the unfolded protein response (UPR) to reduce the protein load in the ER. Under conditions of moderate ER stress, the UPR promotes cell cycle arrest which allows time for successful protein load reduction and enables cell survival. However, under conditions of high levels of ER stress the UPR induces cellular …
Cell Cycle Regulatory Roles Of Estrogen Receptor Alpha (Erα) In Breast Cancer Cells, Sonia Javanmoghaddam
Cell Cycle Regulatory Roles Of Estrogen Receptor Alpha (Erα) In Breast Cancer Cells, Sonia Javanmoghaddam
Dissertations & Theses (Open Access)
Previous studies have shown that Estrogen Receptor alpha (ERα) is an important indicator for diagnosis, prognosis and treatment of breast cancers. However, the question remains as to the role of ERα in the cell in the presence versus absence of 17-β estradiol In this dissertation the role of ERα in both its unliganded and liganded state, with respect to the cell cycle will be explored. The cell line models used in this project are ER-positive MCF-7 cells with and without siRNA to ERα and ER-positive MDA-MB-231 cells that have been engineered to express ERα. Cells were synchronized and the cell …