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Articles 1 - 10 of 10
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Analysis Of The Antimicrobial Activity Of The Novel Chemotherapeutic Drug, Tpp1, Against Pseudomonas Aeruginosa And The Hydrogel Delivery Of Water-Soluble Antimicrobial Compounds, Alex Gasper
Senior Independent Study Theses
Cancer is one of the leading causes of death in the world, and it is commonly linked with bacterial infections that often complicate treatments. Recently, chemotherapeutics have been developed that are able to act as anti-cancer agents using delocalized lipophilic cations (DLCs) that are able to specifically target mitochondrial membranes of cancer cells. TPP1 is a newly developed chemotherapeutic drug that has activity against bladder cancer and melanoma cell lines in vitro. In order to determine if TPP1 has antimicrobial activity, TPP1 was tested against a common bacteria, Pseudomonas aeruginosa, to determine if antimicrobial activity was present. This testing was …
The Effects Of Venlafaxine And Voluntary Exercise On Chronic Unpredictable Stress Induced Anxiety, Marly Mcgowan
The Effects Of Venlafaxine And Voluntary Exercise On Chronic Unpredictable Stress Induced Anxiety, Marly Mcgowan
Senior Independent Study Theses
Anxiety disorders can impair cognition and emotional control, particularly in the face of novel situations, which is concerning due to the high prevalence of such diagnoses. Exposure to unpredictable chronic stress can provide a way to induce anxiety-like behaviors in rodents by disrupting the stress response systems, including the HPA axis and autonomic nervous system. Pharmacological treatments, including SNRIs like venlafaxine, and voluntary exercise are both anxiolytic treatments that can alleviate the impacts of chronic stress. Using unpredictable chronic stress to mimic the human condition, and exposure to venlafaxine and exercise to mitigate the stress, the open field and elevated …
Microplastics As Carrier Of Pahs Released From Oil Spills: Measuring Ingestion And Bioaccumulation Rates In Copepods, Manasi Desai
Microplastics As Carrier Of Pahs Released From Oil Spills: Measuring Ingestion And Bioaccumulation Rates In Copepods, Manasi Desai
Senior Independent Study Theses
Microplastics (MP; plastics < 5mm) are a growing problem in the marine environment due to a large influx of plastics entering the marine environment through rivers, wastewater and litter from land. MP are known to adsorb nonpolar compounds in the water including polycyclic aromatic hydrocarbons (PAHs) released from oil spills. In this study, I quantified the ingestion rates of a marine copepod (Calanus finmarchicus) on clean polystyrene MP beads (12 um) and phenanthrene loaded MP beads (0.8 pg PAH pellet -1). I measured the phenanthrene load in copepods ingesting phenanthrene sorbed MPs and copepods exposed to phenanthrene only to measure the role of MP as a vector for PAHs into marine food webs. Additionally, I examined the fecal pellets to check the presence of MPs and if phenanthrene was still adsorbed to them. The results showed that microplastics do not act as vectors as there was no significant difference between the body load of phenanthrene in copepods from ingestion of PAH sorbed MPs and the body load from passive uptake of phenanthrene in solution. Copepods ate significantly lower phenanthrene loaded MP (1.81 x 104 beads cop-1 day-1) than microplastics only (2.67 x 104 beads cop-1 day-1) suggesting that copepods can reject particles based on chemical content. Accumulation of phenanthrene within the copepods (GC-MS analysis) showed individual copepods can accumulate between 3.48 to 4.11 ng of PAH which potentially can biomagnify in the marine food web upon predation. Fecal pellet analysis showed that an average of 2013 MP beads are present with a mean phenanthrene load of 0.15 pg bead-1. For the social science research, I conducted a literature review examining the current Indian plastic waste management strategies, legislations and its implementation. My results find that the Indian government over the years has progressively enacted and amended its policies to try to keep pace with the issue of plastic pollution. However, key challenges in the implementation such as poor enforcement, inadequate training for recycling lack of plastic alternatives and proper waste disposal infrastructure all contribute to the unsuccessful management of waste. Usage of plastic in road construction has shown to be a viable option in reducing plastic waste in India and also improving road conditions.
The Progression Of Aβ Proteins In The Retrosplenial Cortex Using An App/Ps1 Alzheimer’S Disease Transgenic Rodent Model, Maha H. Rashid
The Progression Of Aβ Proteins In The Retrosplenial Cortex Using An App/Ps1 Alzheimer’S Disease Transgenic Rodent Model, Maha H. Rashid
Senior Independent Study Theses
Alzheimer’s disease is the most common form of dementia in the world with a new case of dementia diagnosed every 3.2 seconds. For over 25 years the amyloid cascade hypothesis has existed as a mechanism of understanding and diagnosing Alzheimer’s Disease. The amyloid cascade hypothesis suggests that Alzheimer’s Disease is sequential in protein progression and proliferative from the medial temporal lobe to the rest of the brain. Hypometabolism of brain regions has also been correlated to plaque deposition and hypometabolism is observed in brain regions that make up the default mode network, specifically the retrosplenial cortex, which is not accounted …
Beyond The Breakfast Club: The Influence Of Breakfast Type On Cognition, Jillian D. Saccogna
Beyond The Breakfast Club: The Influence Of Breakfast Type On Cognition, Jillian D. Saccogna
Senior Independent Study Theses
The glycemic index (“GI”) of a food refers to the magnitude with which the food elevates an individual’s blood glucose levels, and this value can be used to calculate the glycemic load (“GL”) of a specific portion of food. Some evidence suggests that blood glucose levels may play a key role in self-control. Emerging research suggests that consuming low GI or GL breakfasts may enhance memory performance and result in greater levels of positive affect compared to high GI or GL breakfasts. Participants in the present study were randomly assigned to consume either a low GI/GL breakfast or a high …
Attempted Identification Of The Calcium-Dependent Sodium Channel Gene In Paramecium Tetraurelia Using Rnai, Gwendolyn Kuzmishin
Attempted Identification Of The Calcium-Dependent Sodium Channel Gene In Paramecium Tetraurelia Using Rnai, Gwendolyn Kuzmishin
Senior Independent Study Theses
Ion channels play an important role in the swimming behavior of Paramecium tetraurelia. Electrophysiological experiments indicate that a calcium-dependent sodium channel exists in Paramecium, but a gene has not been identified for this channel. It is hypothesized that this channel evolved from a voltage-dependent sodium channel after a whole genome duplication event. In this paper, 13 candidate genes were identified from the Paramecium genome based on their similarity to a reference human voltage-dependent sodium channel. Bioinformatics analysis of the selectivity filter of these putative ion channel genes suggested that at least 8 of the candidate genes were sodium channels …
The Groundwork For Food Criticism: How Normative Aesthetic Judgments Are Possible With Regards To Tastes, Jacob Caldwell
The Groundwork For Food Criticism: How Normative Aesthetic Judgments Are Possible With Regards To Tastes, Jacob Caldwell
Senior Independent Study Theses
Issues of tastes and smells are often relegated to an ancillary or minor rank of importance in the domain of aesthetics, if recognized at all as legitimate objects of aesthetic inquiry and experience. This essay aims, firstly, to carve out a space of legitimacy for the aesthetics of tastes, and secondly, to clarify what aesthetic inquiry with regards to tastes must look like. In order for the above to be decisively established, the following positions will be argued for: (1) tastes are real, (2) our ordinary or scientific conception of what tastes are, upon which our reasons for doubting the …
Learning Emotions: A Software Engine For Simulating Realistic Emotion In Artificial Agents, Douglas Code
Learning Emotions: A Software Engine For Simulating Realistic Emotion In Artificial Agents, Douglas Code
Senior Independent Study Theses
This paper outlines a software framework for the simulation of dynamic emotions in simulated agents. This framework acts as a domain-independent, black-box solution for giving actors in games or simulations realistic emotional reactions to events. The emotion management engine provided by the framework uses a modified Fuzzy Logic Adaptive Model of Emotions (FLAME) model, which lets it manage both appraisal of events in relation to an individual’s emotional state, and learning mechanisms through which an individual’s emotional responses to a particular event or object can change over time. In addition to the FLAME model, the engine draws on the design …
Generalist And Specialist Pollination Syndromes: When Are They Favoured? A Theoretical Approach To Predict The Conditions Under Which A Generalist Or Specialist Pollination Syndrome Is Favoured., Tyler L. Poppenwimer
Generalist And Specialist Pollination Syndromes: When Are They Favoured? A Theoretical Approach To Predict The Conditions Under Which A Generalist Or Specialist Pollination Syndrome Is Favoured., Tyler L. Poppenwimer
Senior Independent Study Theses
No abstract provided.
A Reassessment Of The Conservation Status Of A Critically Endangered Neotropical Frog, Mannophryne Olmonae, Using Occupancy Modeling Techniques, Jessica Mcquigg
A Reassessment Of The Conservation Status Of A Critically Endangered Neotropical Frog, Mannophryne Olmonae, Using Occupancy Modeling Techniques, Jessica Mcquigg
Senior Independent Study Theses
Amphibian species worldwide are threatened with decline and extinction, making species monitoring an important scientific endeavor. The Bloody Bay Poison Frog, Mannophryne olmonae, a Tobago island endemic, was identified as critically endangered by the IUCN in 2004. Recent evidence suggests that a less severe conservation status may be appropriate for M. olmonae. This study employs acoustic calling surveys, land-use information, and multi-year (2011 and 2012) occupancy modeling techniques to propose an appropriate conservation status for this species. This study suggests that M. olmonae occupies a larger geographic range than was previously thought, and is not experiencing population declines. …