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Characterizing Ferroptosis Pathways In In Vitro Motor Neuron Models, Alejandra Martinez
Characterizing Ferroptosis Pathways In In Vitro Motor Neuron Models, Alejandra Martinez
Theses and Dissertations
Ferroptosis is a non-apoptotic regulated form of cell death driven by the toxic accumulation of lipid peroxides and the presence of iron. The mechanism by which ferroptosis operates requires further investigation; here I will discuss the findings regarding the role of ferroptosis in different cellular models as well as the genes that may be involved with either promoting or hindering the ferroptotic pathway. NSC-34 is a hybrid cell line of neuroblastoma and primary spinal cord cells that can be differentiated into a motor neuron-like state allowing the characterization of ferroptosis in two distinct cellular conditions. Additionally, iNIL cells are a …