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Ouachita Baptist University

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Investigating The Mechanism Behind The Cytotoxic Effects Of Ajulemic Acid (Aja) On Ewing's Sarcoma By Employing Smap And Sybyl-X1.3 Surflex Dock Software Programs To Find Receptors For Aja, Rebekah Ward Jan 2014

Investigating The Mechanism Behind The Cytotoxic Effects Of Ajulemic Acid (Aja) On Ewing's Sarcoma By Employing Smap And Sybyl-X1.3 Surflex Dock Software Programs To Find Receptors For Aja, Rebekah Ward

Honors Theses

Ewing's Sarcoma (ES) is a malignant cancer characterized by the formation of tumors in bones or soft tissues of primarily children and young adults. With the tendency for local recurrence and metastasis, ES is an aggressive cancer. The treatment is intensive and often yields poor long-term results. A cannabinoid derived compound, ajulemic acid (AJA), has shown strong cytotoxic effects on ES cell lines. The synthetic compound is unlike its cannabinoid counterpart tetrahydrocannabinol by lacking psychotropic effects. To investigate the possibility of utilizing AJA as a chemotherapeutic drug, the biochemical mechanism behind the cytotoxic effects of AJA needs further research. A …


Using Spheroids And A Bioluminescent Mouse Model To Determine The Effects Of Ajulemic Acid On Ewing's Scarcoma, Drake Hardy Jan 2013

Using Spheroids And A Bioluminescent Mouse Model To Determine The Effects Of Ajulemic Acid On Ewing's Scarcoma, Drake Hardy

Honors Theses

Ewing's Sarcoma is a pediatric bone cancer with a five-year survival rate of only 30%. New treatment options for this highly aggressive disease are desperately needed. Ajulemic acid (AJA), a synthetic cannabinoid, has been the focus of our research, and has demonstratedd the ability to decrease tumor cell viability and inhibit endothelial cell migration and angiogenesis. Based on these results, AJA is a potential therapeutic agent for Ewing's Sarcoma and other solid pediatric cancers. In order to create a realistic environment in vitro in which to study these tumors, we created 3-dimensional spheroids with three cell types, each of which …