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The Effects Of Propofol, Sodium Pentobarbital, And Ketamine Hydrochloride On In Vitro Mouse Embryonic Development, Tyler C. Balak
The Effects Of Propofol, Sodium Pentobarbital, And Ketamine Hydrochloride On In Vitro Mouse Embryonic Development, Tyler C. Balak
Theses and Dissertations in Biomedical Sciences
Every year more than 75,000 pregnant women are exposed to teratogenic medications or general anesthesia during non-obstetric surgery in the US,1-4 and embryonic effects of general anesthesia are of particular interest in laboratory research and veterinary medicine. The mouse system is used to screen potential toxic effects of anesthetics used in egg retrieval for in vitro fertilization (IVF), or those of pharmacologic agents which may come in contact with the egg or early embryo. Mouse preimplantation 2-cell embryos were exposed in vitro to incremental concentrations of common general anesthetics within and exceeding the normal clinical dosage range for mice (propofol …
New Tools For Real-Time Study Of Embryonic Development, Lauren M. Browning
New Tools For Real-Time Study Of Embryonic Development, Lauren M. Browning
Theses and Dissertations in Biomedical Sciences
Embryonic development represents one of the most complex and dynamic cellular processes in biology, and plays vital roles in understanding of functions of embryonic stem cells (ESCs) and design of ESC-based therapy. Conventional assays and fluorescence-based imaging methods have been widely used for the study of embryonic development. These conventional methods cannot effectively provide spatial and temporal resolutions with sufficient sensitivity and selectivity that are required to depict embryonic development in vivo in real-time at single-cell and single-molecule resolutions. In this dissertation, we have developed a wide range of innovative tools for real-time study of embryonic development. These new tools …
Life History Of Stranded Bottlenose Dolphins (Tursiops Truncatus) In Virginia, Margaret Cook Lynott
Life History Of Stranded Bottlenose Dolphins (Tursiops Truncatus) In Virginia, Margaret Cook Lynott
Biological Sciences Theses & Dissertations
Little is known about the life history and overall ecology of bottlenose dolphins that strand in Virginia. In this study, I examined archived life history samples and stranding data from bottlenose dolphins found in Virginia waters to (1) develop growth curves based on ages from sectioned teeth, (2) document characteristics of male and female reproductive organs, and (3) define the relationship between age/length and presence of neonatal characteristics during the first year of life. The Gompertz growth model provided the best fit of growth data for stranded T. truncatus in Virginia. Length at birth and asymptotic length for males were …