Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Genome-Wide Association Study Reveals Genetic Variants Associated With Hiv-1c Infection In A Botswana Study Population, Andrey Shevchenko, Daria V. Zhernakova, Sergey Malov, Aleksey Komissarov, Sofia Kolchanova, Gaik Tamazian, Alexey Antonik, Nikolay Cherkasov, Sergey Kliver, Anastasiia Turenko, Mikhail Rotkevich, Igor Evsyukov, David Vlahov, Prisca K. Thami, Simani Gaseitsiwe, Vladimir Novitsky, Myron Essex, Stephen James O'Brien
Genome-Wide Association Study Reveals Genetic Variants Associated With Hiv-1c Infection In A Botswana Study Population, Andrey Shevchenko, Daria V. Zhernakova, Sergey Malov, Aleksey Komissarov, Sofia Kolchanova, Gaik Tamazian, Alexey Antonik, Nikolay Cherkasov, Sergey Kliver, Anastasiia Turenko, Mikhail Rotkevich, Igor Evsyukov, David Vlahov, Prisca K. Thami, Simani Gaseitsiwe, Vladimir Novitsky, Myron Essex, Stephen James O'Brien
Biology Faculty Articles
Although there have been many studies of gene variant association with different stages of HIV/AIDS progression in United States and European cohorts, few gene-association studies have assessed genic determinants in sub-Saharan African populations, which have the highest density of HIV infections worldwide. We carried out genome-wide association studies on 766 study participants at risk for HIV-1 subtype C (HIV-1C) infection in Botswana. Three gene associations (AP3B1, PTPRA, and NEO1) were shown to have significant association with HIV-1C acquisition. Each gene association was replicated within Botswana or in the United States–African American or United States–European American AIDS …
Genome-Wide Association Study Identifies New Loci Associated With Risk Of Hbv Infection And Disease Progression, Zheng Zeng, Liu Hankui, Xu Huifang, Lu Haiying, Yu Yanyan, Xu Xiaoyuan, Yu Min, Zhang Tao, Tian Xiulan, Xi Hongli, Guan Liping, Zhang Jianguo, Stephen James O'Brien
Genome-Wide Association Study Identifies New Loci Associated With Risk Of Hbv Infection And Disease Progression, Zheng Zeng, Liu Hankui, Xu Huifang, Lu Haiying, Yu Yanyan, Xu Xiaoyuan, Yu Min, Zhang Tao, Tian Xiulan, Xi Hongli, Guan Liping, Zhang Jianguo, Stephen James O'Brien
Biology Faculty Articles
Background: Recent studies have identified susceptibility genes of HBV clearance, chronic hepatitis B, liver cirrhosis, hepatocellular carcinoma, and showed the host genetic factors play an important role in these HBV-related outcomes.
Results: In order to discover new susceptibility genes for HBV-related outcomes, we conducted a genome-wide association study in 1031 Chinese participants, including 275 HBV clearance subjects, 92 asymptomatic persistence infection carriers (ASPI), 93 chronic hepatitis B patients (CHB), 188 HBV-related decompensated cirrhosis patients (DC), 214 HBV-related hepatocellular carcinoma patients (HCC) and 169 healthy controls (HC). In the case-control study, we observed novel locus significantly associated with CHB …