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Forced-Exercise Dependent Changes In Cellular Immunity: Effects On Experimental Autoimmune Neuritis, Michael W. Calik
Forced-Exercise Dependent Changes In Cellular Immunity: Effects On Experimental Autoimmune Neuritis, Michael W. Calik
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Guillain-Barré Syndrome (GBS) is a debilitating inflammatory autoimmune disease of the peripheral nervous system that is characterized by rapid-onset paraparesis with areflexia progressing to neuromuscular paralysis. The most common form of GBS observed in North America and Europe is acute inflammatory demyelinating polyneuropathy (AIDP). Enhanced infiltration of pro-inflammatory type 1 helper T (Th1) cells into peripheral nerves of AIDP patients leads to demyelination.
Increasing evidence supports exercise as an effective rehabilitative intervention. Exercise attenuates the onset and progression of autoimmune diseases. Whether exercise alters the progression of GBS remains unclear.
In this study, we determined the effects of forced-exercise on …