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Fermentable Non-Digestible Dietary Fiber And Bioactive Compounds Affect Aging And Fat Deposition In Caenorhabditis Elegans, Chenfei Gao
LSU Doctoral Dissertations
Overweight and obesity have been imposing $147 billion a year to the health care system in the United States. Limited medications are available in the market with side effects. Surgical treatments are second-line obesity treatments. Short chain fatty acids (SCFAs) produced from the fermentable resistant starch improves the secretion of satiety hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1) from L-endocrine cells of cecum and colon. We hypothesized that consumption of fermentable non-digestible dietary fiber and bioactive compounds will increase insulin sensitivity, reduce body fat, and improve healthspan in Caenorhabditis elegans (C. elegans), and hyperglycemia (2% glucose) that may …