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Insulin Dose Response Curves And Factors Affecting Insulin Sensitivity In Horses, Jeanne D. Lestelle
Insulin Dose Response Curves And Factors Affecting Insulin Sensitivity In Horses, Jeanne D. Lestelle
LSU Master's Theses
Three experiments were conducted to further study the use of intravenous insulin injection to measure insulin sensitivity in horses. In the first experiment, glucose responses to multiple doses of recombinant human insulin were compared in insulin sensitive and insensitive mares. Regression lines describing the responses in insensitive mares had less (P = 0.003) steep slopes and greater (P = 0.006) effective doses at 50% response (ED50) compared to sensitive mares. Curvilinear regression models provided a good fit (R2 = 0.95) for the prediction of ED50 from the individual responses to 50 mU/kg BW insulin. The second experiment estimated the repeatability …
Repeatability Of Prolactin Responses To Sulpiride In Mares And Geldings And The Effect Of Pergolide And Cabergoline, Rebekah C. Hebert
Repeatability Of Prolactin Responses To Sulpiride In Mares And Geldings And The Effect Of Pergolide And Cabergoline, Rebekah C. Hebert
LSU Master's Theses
Four experiments were conducted in an effort to develop a method, based on prolactin secretion, for assessing the efficacy and duration of activity of dopaminergic agonists for the treatment of pituitary pars intermedia dysfunction (PPID) in horses. In the first experiment, prolactin response to a low dose of the dopamine antagonist, sulpiride, was generally repeatable in estrogen-primed geldings in winter over 8 every-other-day challenges. It was concluded that estrogen-primed, sulpiride-challenged geldings in winter could serve as a model for the study of potential dopaminergic drugs for the treatment of PPID in horses. The second experiment was performed in the summer …