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In Vitro And In Vivo Anti-Angiogenic Activities Of Milk Sphingolipids, Rishipal Rastrapal Bansode
In Vitro And In Vivo Anti-Angiogenic Activities Of Milk Sphingolipids, Rishipal Rastrapal Bansode
LSU Doctoral Dissertations
Anti-angiogenic therapies aimed at halting new blood vessel formation are now being extensively studied as inhibitors of excessive angiogenesis. Conversely, compounds with ability to stimulate angiogenesis are being considered as a therapeutic approach for insufficient angiogenesis. Food-borne bioactive compounds such as genistein, resveratrol, curcumin, the Bowman-Birk inhibitor, and catechins are being potentially established as good candidates for angioprevention. The aim of our study was to determine the anti-or pro-angiogenic activity of milk-based glycosphingolipids such as C6-ceramide (Cer), Sphingomyelin (SPM) and Glucosylceramide (GluCer), in vitro, using breast cancer (MCF-7), colon cancer (Caco-2) and prostate cancer (DU-145) cell-lines, on angiogenic factors such …