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Cell-Mediated Cytotoxicity Of Jensen Tumor In Sprague-Dawley Rats, Theodore D. Masek
Cell-Mediated Cytotoxicity Of Jensen Tumor In Sprague-Dawley Rats, Theodore D. Masek
Loma Linda University Electronic Theses, Dissertations & Projects
An in vitro system for the study of the cell-mediated immune response to Jensen Sarcoma (JS) is described. The tumor grew unrestricted and lead to the demise of 80% of successfully challenged Sprague-Dawley rats (persistors) while 20% of challenged rats (regressors) destroyed the tumor by an unknown mechanism(s). Lymphocytes from both persistors and regressors were shown to be cytotoxic for tumor cells in vitro. Pretreatment of tumor target cells with "immune" serum from persistors or regressors had no effect on the in vitro cytotoxicity of lymphocytes from tumor-challenged rats. Pretreatment of lymphocytes with irmnune serum, however, was shown to reduce …
An Electrophysiological Analysis Of The Primary Input To The Cat Prepyriform Cortex, George Maeda
An Electrophysiological Analysis Of The Primary Input To The Cat Prepyriform Cortex, George Maeda
Loma Linda University Electronic Theses, Dissertations & Projects
Properties of the lateral olfactory tract (LOT) action potential and cortical evoked potential (EPSP) were studied using discrete stimuli applied to the tract in acute and chronic preparations. Stimulus response curves for both presynaptic (action) and postsynaptic (EPSP) potentials were sigmoidal and linearly related over the entire range. Simulated action potentials were used to determine the diameter to amplitude relationship, an intermediate step for finding the threshold as a function of tract axon diameter. Our results indicate that threshold is proportional to (diameter) -3.4 instead of (diameter) -1 as found by others in frog peripheral nerve. Further work is required …
Immunological Responses In The Prairie Rattlesnake Crotalus Viridis Viridis Rafinesque 1818, To Laboratory Infection With Tetrathyridia Of Mesocestoides Corti Hoeppli 1925 (Eucestoda : Mesocestoididea), Gray Bruce Hanson
Loma Linda University Electronic Theses, Dissertations & Projects
Prairie rattlesnakes, of the species Crotalus viridis virldis, were orally, infected with tetrathyridia of Mesocestoides corti to determine the host response to the parasite. Snakes were maintained at constant temperatures of 25, 30, and 35 C for 4--24 weeks. Blood chemistry evaluations of the host were made by standard hematological methods. Eosinophil counts, total proteins, and serum gamma globulins increased while packed-cell volumes and hemoglobins decreased. Autopsy studies revealed the first documented asexual multiplication of Mesocestoides corti in a laboratory infected ectothemic host, with the small intestine being the preferred organ. Pseudocyst formation was first observed to occur at 4 …
The Analysis Of A Substrate Preference Of Peromyscus (Rodentia: Cricetidae), Bruce E. Buttler
The Analysis Of A Substrate Preference Of Peromyscus (Rodentia: Cricetidae), Bruce E. Buttler
Loma Linda University Electronic Theses, Dissertations & Projects
The preference for a rocky situation was analyzed under laboratory conditions. In three-compartmented choice boxes, Peromyscus californicus and P. eremicus chose a compartment with rocks and a sandy floor over a compartment with just a sandy floor but P. maniculatus did not show a preference. In a similar experiment, in continual total darkness, the three species chose the compartment with the rocks. UM-key did not prefer the compartment with rocks when the rocks were encased in plastic and were under a normal light regime. When allowed a choice between an empty dark compartment and an empty lighted compartment exposed to …
Effects Of Temperature On Calcium Uptake In Bossiella Orbigniana Orbigniana, Carolyn M. Thomas
Effects Of Temperature On Calcium Uptake In Bossiella Orbigniana Orbigniana, Carolyn M. Thomas
Loma Linda University Electronic Theses, Dissertations & Projects
The effect of temperature on calcification in Bossiena orbigniana orbigniana (Decaisne, 1842) [Manza, 1940; Silva, 1957] (Corallinaceae) was studied using calcium-45 labeling of terminal segments under laboratory conditions. B. orbigniana has optimum calcium uptake for the temperatures 17-21°C within a temperature range of 3-37°C. These results suggest that optimum calcification in B. orbigniana should take place from late spring to early autumn. Q10 values for 3-21°C averaged 3.39 indicating an enzyme-governed reaction. It is proposed that thallus growth rate and calcification are not directly related. It is believed that the optimum temperatures (17-21°C) affect the enzymes towards an increase …
Concurrent Infection Of Trypanosoma Musculi Kendell, 1906, And Schistosoma Mansoni Sambon, 1907 In Mice, Berhane Andeberhan
Concurrent Infection Of Trypanosoma Musculi Kendell, 1906, And Schistosoma Mansoni Sambon, 1907 In Mice, Berhane Andeberhan
Loma Linda University Electronic Theses, Dissertations & Projects
The possible effects of ablastin on Schistosoma mansoni were investigated by (1) establishing a concurrent infection of Trypanosoma musculi and Schistosoma mansoni in mice, and (2) by obtaining Trypanosoma lewisi immune rat serum (ablastin) and injecting it into S. mansoni infected mice. These procedures were followed on days 4, 14 and 28 of S. mansoni infection. For the groups that were given immune rat serum, controls were kept into which normal rat serum was injected.
Ablastin does not have any effect on the development or morphology of the S. mansoni worms as tested in this study. Although ablastin inhibits glycolytic …
Comparison Of Two Techniques For Enumeration Of Human B And T Lymphocytes, William F. Forsythe Jr.
Comparison Of Two Techniques For Enumeration Of Human B And T Lymphocytes, William F. Forsythe Jr.
Loma Linda University Electronic Theses, Dissertations & Projects
The assay of Bursa-derived and Thymus-derived lymphocytes (B and T cells) in man has become increasingly useful during the past few years in normal and in clinical conditions. There has been quite a range reported in the literature in the percent of B and T cells in normal subjects by different investigators.
The purpose of this study was to see if monocyte contamination was one cause of non-specific rosette formation. Twenty-one subjects were used to compare the technique involving trypsin and neuraminidase treatment of erythrocytes and the technique of glass wool removal of monocytes. A peroxidase stain was used to …
Effects Of Cariogenic And Noncariogenic Diets On The Concentration Of The Parotid Hormone Releasing Factor In Rat Hypothalami, Melva Joan Brown
Effects Of Cariogenic And Noncariogenic Diets On The Concentration Of The Parotid Hormone Releasing Factor In Rat Hypothalami, Melva Joan Brown
Loma Linda University Electronic Theses, Dissertations & Projects
Hypothalamic and cortical extracts from various cariogenically grouped rats which had been maintained on either a Purina diet or a high sucrose diet (HSD) for three months were infused intravenously into 28 days old rats to determine if there was a titer of parotid hormone releasing factor (PRF) capable of facilitating fluid movement (FM) in the teeth. The hypothalamic and cortical extracts obtained from Purina-fed rats with 0-caries and the hypothalamic extracts from BSD-fed rats conclusively demonstrated FM stimulatory ability. Other Purina-fed groups were essentially biologically ineffective, however, extracts from HSD-fed caries groups including scores 11-40 demonstrated extremely potent FM …
Determination Of Lead Content In Apical Tissue Following Root Canal Obturation With Sargenti's Formula, G. Merle Hickok
Determination Of Lead Content In Apical Tissue Following Root Canal Obturation With Sargenti's Formula, G. Merle Hickok
Loma Linda University Electronic Theses, Dissertations & Projects
Four Stump-tail monkeys were used to help determine if the lead in Sargenti's formula diffuses out into the apical tissue while confined entirely within the root canal. In each animal two teeth were filled with Sargenti's formula 1-2 millimeters short of the radiographic apex, and two teeth were filled with gutta percha and Proco-Sol sealer for controls, making a total sample size of sixteen. The time ranged from 48 hours to 120 days. Lead analysis using the spectrophotometric method showed a higher lead content in the teeth filled with Sargenti's formula than with the gutta percha controls.
Histology Of Apical Tissue : A Comparative Study Of Sargenti Formula, Short Vs. Overfill, James G. Schulze
Histology Of Apical Tissue : A Comparative Study Of Sargenti Formula, Short Vs. Overfill, James G. Schulze
Loma Linda University Electronic Theses, Dissertations & Projects
Four Stump-tail monkeys (Macaca spiciosa) were used for this study to analyze, on a cellular level, the apical tissue of teeth overfilled versus teeth filled short 1-3 mm. of the radiographic apex with the Sargenti formula. In each animal four incisors were filled short and four incisors were overfilled. A final sample size consisted of 28 teeth. The time periods ranged from 48 hours to 120 days. After analysis of the histology it can be stated that the teeth filled short showed no inflammation to moderate inflammation in the periapical tissues. In teeth overfilled there was a range from moderate …
The Effect Of A High Polyunsaturated, High Fiber, Lacto-Vegetarian Diet On The Serum Cholesterol And Serum Triglycerides In Human Subjects, Linda Johnson
Loma Linda University Electronic Theses, Dissertations & Projects
Fifteen male high risk coronary subjects were fed a lacto-vegetarian diet for 28 days. The diet was calculated with a P:S ratio of 4.0 or greater and the subjects received at least 10 g. of fiber per day. At weekly intervals, the blood was drawn and serum cholesterol and triglyceride determinations were done. As a result of the diet, the men experienced a significant decrease in cholesterol (p>.001). During the 28 days, there was a 29 percent decrease in mean serum cholesterol and a 40 percent decrease in mean serum triglycerides.